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Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG-U133_Plus_2]

ABSTRACT: Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG-U133_Plus_2]

PROVIDER: PRJNA414183 | ENA |

REPOSITORIES: ENA

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Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG-U133_Plus_2]

Project description:Glucocorticoid (GC)- sensitive cells are killed by receptor (GR)-filling concentrations of GC for a sufficient time. We used 2 closely related clones ( sensitive, 1 resistant) from the CEM line of ALL cells to test the hypothesis that at this early pre-apoptosis time, a distinct set of regulated genes would be found in the sensitive clones, with cross-talk to other significant pathways

2017-10-14 | GSE104931 | GEO

Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG_U95Av2]

Project description:Glucocorticoid (GC)- sensitive cells are killed by receptor (GR)-filling concentrations of GC for a sufficient time. We used 3 closely related clones (2 sensitive, 1 resistant) from the CEM line of ALL cells to test the hypothesis that over time, a distinct set of regulated genes would be found in sensitive clones, with cross-talk to other significant pathways

2017-10-14 | GSE104930 | GEO

Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells

Project description:Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells

| PRJNA414180 | ENA

Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG_U95Av2]

Project description:Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells [HG_U95Av2]

| PRJNA414184 | ENA

Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-10-14 | GSE104932 | GEO

Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells:interactions of MAPK, MYC and glucocorticoid pathways.

Project description:Gene expression responses to glucocorticoid (GC) in the hours preceding onset of apoptosis were compared in three clones of human acute lymphoblastic leukemia CEM cells. Between 2 and 20h, all three clones showed increasing numbers of responding genes. Each clone had many unique responses, but the two responsive clones showed a group of responding genes in common, different from the resistant clone. MYC levels and the balance of activities between the three major groups of MAPKs are known important regulators of glucocorticoid-driven apoptosis in several lymphoid cell systems. Common to the two sensitive clones were changed transcript levels from genes that decrease amounts or activity of anti-apoptotic ERK/MAPK1 and JNK2/MAPK9, or of genes that increase activity of pro-apoptotic p38/MAPK14. Down-regulation of MYC and several MYC-regulated genes relevant to MAPKs also occurred in both sensitive clones. Transcriptomine comparisons revealed probable NOTCH-GC crosstalk in these cells.

| S-EPMC6075652 | biostudies-literature

Human CEM Cells: Control vs. 2h or 4.5h Cluvenone Treated

Project description:Transcriptional profiling of human CEM cells comparing control untreated CEM cells with either 2h or 4.5h cluvenone-treated CEM cells.

2010-08-11 | GSE23536 | GEO

Human CEM Cells: Control vs. 2h or 4.5h Cluvenone Treated

Project description:Transcriptional profiling of human CEM cells comparing control untreated CEM cells with either 2h or 4.5h cluvenone-treated CEM cells. Two-timepoint experiment, CEM vs. Cluvenone-Treated CEM (2h and 4.5h). Biological replicates: 4 control, 4 2h-treated, 4 4.5h-treated, independently grown and harvested. Pooled controls. One replicate per array.

2010-08-11 | E-GEOD-23536 | biostudies-arrayexpress

Expression data from glucocorticoid-treated ALL (CCRF-CEM-C7-14 cells)

Project description:The beneficial effects of glucocorticoids (GCs) in acute lymphoblastic leukemia (ALL) are based on their ability to induce apoptosis. Omics technologies such as DNA microarray analysis are widely used to study the changes in gene expression and have been successfully implemented in biomarker identification. In addition, time series studies of gene expression enable the identification of correlations between kinetic profiles of glucocorticoid receptor (GR) target genes and diverse modes of transcriptional regulation. This study presents a genome-wide microarray analysis of both our and published Affymetrix HG-U133 Plus 2.0 data in GCs-sensitive and -resistant ALL. GCs-sensitive CCRF-CEM-C7-14 cells were treated with dexamethasone at three time points (0 h, 2 h and 10 h). The treated samples were then compared to the control (0 h). Dexamethasone-treated CCRF-CEM-C7-14 samples were divided into 3 groups based on time points: the untreated control (0 h), 2 h and 10 h.

2012-09-01 | E-GEOD-39338 | biostudies-arrayexpress

Clear cell renal cell carcinoma (ccRCC) samples

Project description:To select signatures of ccRCC, 265 ccRCC samples were obtained from the Van Andel Research Institute. Gene expression profiles of 265 samples were determined using the HG-U133_Plus_2 platform.

2017-08-08 | GSE73731 | GEO

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