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MicroRNA-triggered transposon small RNAs mediate genome dosage response (sRNA-Seq)

ABSTRACT: microRNA-triggered transposon small RNAs mediate genome dosage response (sRNA-Seq)

PROVIDER: PRJNA415633 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6208920.fastq.gz	Fastqsanger.gz
	SRR6208921.fastq.gz	Fastqsanger.gz
	SRR6208912.fastq.gz	Fastqsanger.gz
	SRR6208913.fastq.gz	Fastqsanger.gz
	SRR6208914.fastq.gz	Fastqsanger.gz

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Project description:Chromosome dosage plays a significant role in reproductive isolation and speciation in both plants and animals, but underlying mechanisms are largely obscure. Transposable elements can promote hybridity through maternal small RNA, and have been postulated to regulate dosage response via neighboring imprinted genes. Here, we show that a highly conserved microRNA in plants, miR845, targets the tRNAMet primer-binding site (PBS) of LTR-retrotransposons in Arabidopsis pollen, and triggers the accumulation of 21 to 22-nucleotide small RNA in a dose dependent fashion via RNA polymerase IV. We show that these epigenetically activated small-interfering RNAs (easiRNAs) mediate hybridization barriers between diploid seed parents and tetraploid pollen parents (“the triploid block”), and that natural variation for miR845 may account for “endosperm balance” allowing formation of triploid seeds. Targeting the PBS with small RNA is a common mechanism for transposon control in mammals and plants, and provides a uniquely sensitive means to monitor chromosome dosage and imprinting in the developing seed.

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microRNA-triggered transposon small RNAs mediate genome dosage response (Bisulfite-Seq)

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Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis.

Project description:Chromosome dosage has substantial effects on reproductive isolation and speciation in both plants and animals, but the underlying mechanisms are largely obscure 1 . Transposable elements in animals can regulate hybridity through maternal small RNA 2 , whereas small RNAs in plants have been postulated to regulate dosage response via neighboring imprinted genes3,4. Here we show that a highly conserved microRNA in plants, miR845, targets the tRNAMet primer-binding site (PBS) of long terminal repeat (LTR) retrotransposons in Arabidopsis pollen, and triggers the accumulation of 21-22-nucleotide (nt) small RNAs in a dose-dependent fashion via RNA polymerase IV. We show that these epigenetically activated small interfering RNAs (easiRNAs) mediate hybridization barriers between diploid seed parents and tetraploid pollen parents (the 'triploid block'), and that natural variation for miR845 may account for 'endosperm balance' allowing the formation of triploid seeds. Targeting of the PBS with small RNA is a common mechanism for transposon control in mammals and plants, and provides a uniquely sensitive means to monitor chromosome dosage and imprinting in the developing seed.

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microRNA-triggered transposon small RNAs mediate genome dosage response

Project description:This SuperSeries is composed of the SubSeries listed below.

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