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Transcript analysis of CD45+Ter119+CD71+ erythroid-like progenitor cells from tumor-bearing mice

ABSTRACT: Transcript analysis of CD45+Ter119+CD71+ erythroid-like progenitor cells from tumor-bearing mice

PROVIDER: PRJNA416659 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6240100_1.fastq.gz	Fastqsanger.gz
	SRR6240100_2.fastq.gz	Fastqsanger.gz
	SRR6240110_1.fastq.gz	Fastqsanger.gz
	SRR6240110_2.fastq.gz	Fastqsanger.gz
	SRR6240101_1.fastq.gz	Fastqsanger.gz

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Transcript analysis of CD45+Ter119+CD71+ erythroid-like progenitor cells from tumor-bearing mice

Project description:We report the application of RNA sequencing technology for high-throughput profiling of transcriptome in mammalian cells. By this method, we report that the CD45+ EPC transcriptome resembled that of MDSCs. Mechanistically, like MDSCs, production of reactive oxygen species is a major mechanism for EPC-mediated immunosuppression.

2018-10-29 | GSE106384 | GEO

Expression data from the spleen of tumor bearing mice

2014-12-19 | GSE58468 | GEO

Expression data from the spleen of tumor bearing mice

Project description:We identify a new cell subset Ter119+CD45- small cells that promotes tumor metastasis in hepatocellular carcinoma (HCC)-bearing mice. We used microarrays to detail the gene expression of Ter119+CD45- cells comparing with CD45- cells in the spleen of hepatocellular carcinoma (HCC)-bearing mice. Ter119+CD45- cells in the spleen of hepatocellular carcinoma (HCC)-bearing mice, being sorted by a MoFlo high-speed cell sorter, were prepared for RNA extraction and hybridization on Affymetrix microarrays. The CD45+ cells from the same tumor bearing mice were prepared as control.

2014-12-19 | E-GEOD-58468 | biostudies-arrayexpress

Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis

Project description:Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during embryonic development. Rcor1 mutant proerythroblasts, unlike normal cells, can form myeloid colonies in vitro. To investigate the underlying molecular mechanisms for block of erythropoiesis and increased myeloid potential, we used RNA-seq to reveal the differentially expressed genes from erythroid progenitors due to depletion of Rcor1. RNA were extracted from FACS sorted CD71+,TER119- erythroid progenitors from control (Rcor1+/+ and Rcor1+/-) or Mutant (Rcor1-/- ) E13.5 fetal liver. Each library was made by pooling RNA from several fetal livers. Two biological replicates were made for either control or mutant condition.

2014-06-03 | E-GEOD-50708 | biostudies-arrayexpress

RNA-Seq analysis of microRNA expression profiles in mouse primary CFU-E late erythroid progenitors and Ter119+ mature erythroblasts

Project description:Using RNA-seq technology, we quantitatively determined the expression profile of microRNAs during mouse terminal erythroid differentiation. CFU-E erythroid progenitors were isolated from E14.5 fetal liver as the Ter119, B220, Mac-1, CD3 and Gr-1 negative, C-Kit positive and 20% high CD71 population. Mature Ter119+ erythroblasts were isolated from E14.5 fetal liver as C-Kit negative and Ter119 positive population. Consistent with nuclear condensation and global gene expression shut down during terminal erythroid differentiation, we found that the majority of microRNAs are downregulated in more mature Ter119+ erythroblasts compared with CFU-E erythroid progenitors.

2011-06-09 | GSE25602 | GEO

RNA-Seq analysis of microRNA expression profiles in mouse primary CFU-E late erythroid progenitors and Ter119+ mature erythroblasts

2011-06-09 | E-GEOD-25602 | biostudies-arrayexpress

CD71+ HSC/MPP

Project description:We describe the unique enrichment of erythroid-megakaryocyte primed CD71+ phenotypic HSC/MPPs in steady-state PB.

2021-12-17 | GSE191084 | GEO

Gene expression analysis from erythroid progenitors of patients with Diamond-Blackfan anemia

Project description:Gene expression analysis from erythroid progenitors (CD34+/CD71(high)/CD45- mononuclear cells from the bone marrow) of patients with Diamond-Blackfan anemia (due to RPS19 mutations) and control individuals.

2014-02-28 | GSE41817 | GEO

Expression profiling of erythroid developmental subsets isolated from mouse fetal liver.

Project description:The S1 and S3 erythroid developmental subsets were isolated using flow cytometry and the cell surface markers CD71 and Ter119 as described by Pop et. al. 2010 (PMID: 20877475) Expression profiles for S1 and S3 subsets were generated using Affymetrix GeneChips. Results were used to identify genes that are differentially expressed during erythropoiesis.

2011-10-31 | GSE32214 | GEO

Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells

Project description:Ter-119 is a better murine erythroid selection marker than CD71 for bulk immunomics, murine bone marrow and fetal liver erythroid cells have different antimicrobial immune transcriptome signatures, murine bone marrow erythropoiesis is comprised of two branches In this study, we decided to benchmark erythroid cells’ selection and enrichment markers – CD71 and Ter-119 via bulk immune transcriptomics by Nanostring and perform bulk immune transcriptome profiling of Ter-119+ erythroid cells from the bone marrow and the fetal liver by Nanostring.

2023-07-31 | GSE238190 | GEO

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