Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Unionoidae (Freshwater mussels)

ABSTRACT: Deciphering the link between doubly uniparental inheritance of mtDNA and sex determination in bivalves: clues from comparative transcriptomics

PROVIDER: PRJNA417279 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6279380_1.fastq.gz	Fastqsanger.gz
	SRR6279380_2.fastq.gz	Fastqsanger.gz
	SRR6279381_1.fastq.gz	Fastqsanger.gz
	SRR6279381_2.fastq.gz	Fastqsanger.gz
	SRR6279382_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Ruditapes philippinarum

Project description:De Novo assembly of the Manila clam Ruditapes philippinarum transcriptome provides new insights into expression bias, mitochondrial doubly uniparental inheritance and sex determination

| PRJNA68513 | ENA

Project description:Mitonuclear sex determination? Empirical evidence from bivalves

| PRJNA926666 | ENA

POLDIP2 is required for mtDNA elimination during spermatogenesis to ensure maternal inheritance in Drosophila melanogaster

Project description:Maternal inheritance of mitochondrial DNA (mtDNA) is highly conserved in metazoans. While many species eliminate paternal mtDNA during late sperm development to foster maternal inheritance, the regulatory mechanisms governing this process remain elusive. Through a large-scale genetic screen in Drosophila, we identified 47 mutant lines exhibiting substantial retention of mtDNA in mature sperm. We mapped one line to Poldip2, a gene predominantly expressed in the testis. Disruption of Poldip2 led to pronounced mtDNA retention in mature sperm and subsequent paternal transmission to progeny. Further investigation via imaging, biochemical analyses and ChIP assays revealed that POLDIP2 is a mitochondrial matrix protein capable of binding to mtDNA. Moreover, we uncovered that CLPX, a key component of the major mitochondrial protease, binds to POLDIP2 to co-regulate mtDNA elimination in Drosophila spermatids. This study shed light on the mechanisms underlying mtDNA removal during spermatogenesis, underscoring the pivotal role of this process in safeguarding maternal inheritance.

2024-06-04 | E-MTAB-14100 | biostudies-arrayexpress

RNA-seq analysis of POLDIP2 mutant in Drosophila melanogaster

2024-06-10 | E-MTAB-14104 | biostudies-arrayexpress

Detection of uniparental disomy from genome sequencing of family trio

Project description:We created a bioinformatics pipeline to detect uniparental disomy from whole genome sequence data of family trios. We use inheritance patterns of single nucleotide polymorphisms to identify uniparental disomy events.

| EGAS00001006154 | EGA

Mitochondrial DNA sequences of familial (maternal vs. non-maternal) ALS cases in whole blood, platelets and white blood cells

Project description:To address the question of whether mtDNA mutations might play a role in familiar ALS (fALS), mtDNA was isolated from whole blood (WB), white blood cells (WBC) and platelets (PLT) from fALS patients and the mitochondrial genome was analyzed using a mtDNA resequencing array (Affymetrix MitoChip v2.0) that allows detection of low-level heteroplasmy in addition to the conventional homoplasmic or heteroplasmic mutations. We distinguished between fALS cases with a prominent maternal (mat) inheritance pattern and fALS cases that do not point to a maternal inheritance pattern (non-mat). As additional controls we compared our results to healthy age and sex matched individuals without any known neurodegenerative background. With this we are aiming to get a deeper insight into a possible role of mtDNA alterations acting as a disease modifier in a subgroup of ALS patients presenting with a maternal transmission of the disease.

2023-07-28 | GSE211250 | GEO

Concurrent activation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion

Project description:Comparison of transcriptome between control, NF-kB, Notch and NF-kB singly- and doubly-activated spleen marginal zone or precursor B cells, and transformed doubly-activated lymphoma cells

2021-07-11 | GSE116960 | GEO

Slaviero2021 - E. coli anaerobic central carbon and energy metabolism_Version1

Project description:This model describes the central carbon and energy metabolism of E. coli growing under anaerobic conditions. For complete information about the model see: 'Deciphering the physiological response of Escherichia coli under high ATP demand Simon Boecker, Giulia Slaviero, Thorben Schramm, Witold Szymanski, Ralf Steuer, Hannes Link, Steffen Klamt Mol Syst Biol. (2021) 17: e10504https://doi.org/10.15252/msb.202110504'

2022-02-13 | MODEL2202020001 | BioModels

Pollutants bioavailability and toxicological risk from NSAIDs to marine mussels

Project description:Pharmaceutical compounds are emerging contaminants in aquatic environment due to their massive use (human and veterinary medicines, agriculture and aquaculture) and a limited removal by waste water treatment plants (WWTPs). In this work, a representative determination of ecotoxicological potential of two different NSAIDs compounds was studied in the sensitive bioindicator marine organism M. Galloprovincialis. Mussels were exposed, under regulated laboratory conditions, to Ketoprofen (KET) and Nimesulide (NIM), dosed alone at the realistic environmental concentration of 0.5µg/L for 14 days. Gene expression analyses of Mytilus galloprovincialis exposed to KET and NIM have been performed through a DNA microarray platform.

2016-02-22 | GSE66990 | GEO

Mussels

Project description:Analysis of circulating cell-free DNA from Mytilus platensis and Aulacomya atra.

| PRJNA531893 | ENA