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Investigate A2M treatment on human prostate cancer xenograft in mice

ABSTRACT: Investigate A2M treatment on human prostate cancer xenograft in mice

OTHER RELATED OMICS DATASETS IN: GSE107195GSE107194

PROVIDER: PRJNA418738 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6297860.fastq.gz	Fastqsanger.gz
	SRR6297861.fastq.gz	Fastqsanger.gz
	SRR6297862.fastq.gz	Fastqsanger.gz
	SRR6297863.fastq.gz	Fastqsanger.gz
	SRR6297864.fastq.gz	Fastqsanger.gz

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Similar Datasets

Investigate A2M treatment on human prostate cancer xenograft in mice

Project description:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumor development. Here we found that A2M modulates tumor cell adhesion, migration and growth by inhibition of tumor promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumor xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumor cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumor promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

2018-01-25 | GSE106989 | GEO

Investigate A2M treatment on human prostate cancer and mouse liver

Project description:Investigate A2M treatment on human prostate cancer and mouse liver

| PRJNA419249 | ENA

Investigate A2M treatment in liver of mice

Project description:Investigate A2M treatment in liver of mice

| PRJNA419257 | ENA

Investigate A2M treatment in liver of mice

Project description:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

2018-01-30 | GSE107194 | GEO

single cell RNA sequencing of xenograft prostate cancer model under different treatment

Project description:We performed single cell RNA sequencing of xenograft prostate cancer models to analyse effect of different drugs.

2022-02-17 | GSE189519 | GEO

single cell RNA sequencing of xenograft prostate cancer model under different treatment

Project description:single cell RNA sequencing of xenograft prostate cancer model under different treatment

| PRJNA783314 | ENA

Transcriptome profiling of A2M treated A549 Cell Line Samples

Project description:The goal of the study was to identify changes in transcriptome expressions upon treatment of A549 cell line samples with activated A2M.

2018-01-23 | GSE106261 | GEO

Investigate A2M treatment on human prostate cancer and mouse liver

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-01-25 | GSE107195 | GEO

Patient Derived Xenograft for Delivery of Precision Medicine in Castrate Resistant Prostate Cancer

Project description:Developing animal models representating the cancer biology of advanced prostate cancer patients is challenging but essential for delivering individualized medical therapies. In an effort to develop patient derived xenograft (PDX) models, we took the metastatic site tissue from the rib lesion twice (ie, before and after enzalutamide treatment) over a twelve week period and implanted subcutaneously and under the renal capsule in immuno-deficient mice. To characterize and compare the genome and transcriptome landscapes of patient tumor tissues and the corresponding PDX models, we performed whole exome and transcriptome sequencing for metastatic tumor tissue as well as its derived PDXs. We demonstrated the feasibility of developping PDX models from patient who developed castrate-resistant prostate cancer. Our data suggested PDX models preserve the patient’s genomic and transcriptomic alterations in high fidelity, as illustrated by somatic mutation, copy number variation, gene fusion and gene expression. RNA sequencing of prostate cancer tumor tissue and derived xenograft using Illumina HiSeq 2000.

2015-06-30 | E-GEOD-70380 | biostudies-arrayexpress

Expression in prospectively purified human prostate orthotopic xenograft tumor cells with varying S/TFE

Project description:This SuperSeries is composed of the following subset Series: GSE25690: Global analysis of mRNA expression in prospectively purified human prostate orthotopic xenograft tumor cells with varying S/TFE. GSE25691: Global analysis of miRNA expression in prospectively purified human prostate orthotopic xenograft tumor cells with varying S/TFE. Refer to individual Series

2010-12-06 | E-GEOD-25692 | biostudies-arrayexpress

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