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RNA-sequencing of bulk CD19+ Thymic B cells from mice and humans

ABSTRACT: RNA-sequencing of bulk CD19+ Thymic B cells from mice and humans

PROVIDER: PRJNA419004 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6305410.fastq.gz	Fastqsanger.gz
	SRR6305420.fastq.gz	Fastqsanger.gz
	SRR6305411.fastq.gz	Fastqsanger.gz
	SRR6305421.fastq.gz	Fastqsanger.gz
	SRR6305412.fastq.gz	Fastqsanger.gz

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Project description:Thymic B cells have been recently shown the ability to be licensed to express Aire, a critical transcription factor involved in the expression of self-antigens in the thymus which are critical for clonal deletion of autoreactive T cells and maintenance of self-tolerance. Mutations in AIRE cause systemic autoimmunity in humans and autoimmunity with varying degrees of severity in different mouse strains. Thymic B cells have been studied in young animals, but studies of this population with age are lacking. Given the thymus undergoes age-associated atrophy in its stromal compartment, we hypothesized that aged thymic B cells may under go changes with age which may impact their ability to mediate clonal deletion of autoreactive T cells and may contribute to age-associated increases in autoimmune prevalence. By comparing the transcriptome of young and aged thymic B cells we find that Aire and transcriptional activators of Aire are signficantly decreased with age.

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RNA-sequencing of bulk CD19+ Thymic B cells from mice and humans

Project description:This SuperSeries is composed of the SubSeries listed below.

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BCR repertoire analyis of class-switched and non-switched thymic B cells

Project description:We report that a large percentage of thymic B cells undergo class switching intrathymically. Thymic B cell class switching requires cognate T-B interaction. To determine whether B cell specificity was also important for thymic B cell class-switching, we sorted class-switched thymic B cells (CD19+B220+IgM-IgD-), unswitched B cells (CD19+B220+IgM+IgD+) and bulk splenic B cells in 3H9 heavy chain-fixed mice and performed high throughput sequencing analysis of the light chain of these populations. Results of this analysis indicated that class-switched thymic B cells have a distinct repertoire compared with unswitched thymic B cells and splenic B cells. Further reactivity tests indicated that a large part of BCRs enriched in class-switched thymic B cells are autoreactive. These data suggest that autoreactive B cells are selected into class-switched population and expanded in the thymus. Light chain repertoire profiles of class-switched thymic B cells, unswithced thymic B cells and splenic B cells from 3H9 mice were generated by deep sequencing.

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