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Endogenous hippocampal leptin in mediating strong potentiation by Astaxanthin supplementation for mild exercise-enhanced neurogenesis and memory functions

ABSTRACT: Endogenous hippocampal leptin in mediating strong potentiation by Astaxanthin supplementation for mild exercise-enhanced neurogenesis and memory functions

PROVIDER: PRJNA419754 | ENA |

REPOSITORIES: ENA

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Endogenous hippocampal leptin in mediating strong potentiation by Astaxanthin supplementation for mild exercise-enhanced neurogenesis and memory functions

Project description:Although exercise and dietary interventions on cognitive function have been investigated, synergistic interactions remain unclear. As tested on hippocampus-dependent functions, mild exercise (ME) or astaxanthin (AX), a naturally-occurring antioxidant and cognitive enhancer, each boost the hippocampus-related memory and neurogenesis. Here we show that leptin (LEP) is required for the synergistic enhancement of hippocampal function by a combination of ME and AX. In C57BL/6J mice, ME or AX alone enhanced spatial memory and neurogenesis, but the enhancement was greater with their combination. DNA microarray analysis showed that the up-regulation of the Lep gene by ME alone was further elevated when combined with AX. The combined interventions synergistically increased hippocampal LEP protein, which was positively correlated with memory enhancement. In LEP-deficient mice, the combined interventions did not enhance memory compared to ME alone, leading us to suggest that the brain-derived LEP has an essential role for the synergistic effect on hippocampal functions.

2017-11-25 | GSE107314 | GEO

Differential transcriptomic expression of an imprved astaxanthin production

Project description:The differential expression of the high-yield astaxanthin Phaffia rhodozyma BPAX-A1 with the wild-type Phaffia rhodozyma CBS6938 was obtained and analysed to understand metabolic changes leading to an improved astaxanthin production.

2023-09-14 | GSE213476 | GEO

Astaxanthin Supplementation Counters Exercise-Induced Decreases in Immune- Related Plasma Proteins

Project description:Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory, and anti-inflammatory effects during physiological stress. The primary objective of this study was to examine the efficacy of 4-weeks ingestion of astaxanthin in moderating exercise-induced inflammation and immune dysfunction using a multi-omics approach.

2023-05-10 | PXD040503 | Pride

Hepatic transcriptome profiles of mice with diet-induced nonalcoholic steatohepatitis treated with astaxanthin and vitamin E

Project description:Astaxanthin alleviates hepatic lipid accumulation and peroxidation, inflammation, and fibrosis in mice with high-cholesterol, high-cholate, and high-fat (CL) diet-induced nonalcoholic steatohepatitis (NASH). It has been proposed as a potential new treatment to inhibit the progression of NASH in humans. Therefore, we compared hepatic gene expression profiles after treatment with astaxanthin or the antioxidant vitamin E in mice with CL diet-induced NASH. Comprehensive gene expression analyses of the livers of mice fed a standard, CL, or CL diet containing astaxanthin or vitamin E for 12 weeks were performed using a DNA microarray. Both astaxanthin and vitamin E effectively improved gene expression associated with eukaryotic initiation factor-2 (EIF2) signaling, which is suppressed in NASH by endoplasmic reticulum (ER) stress in the liver. Astaxanthin but not vitamin E was predicted to suppress the actions of ligand-dependent nuclear receptors peroxisome proliferator-activated receptors (PPAR) α and PPARδ and to affect related molecules. Establishing a new therapy using astaxanthin will require elucidation of astaxanthin’s molecular action on the functions of PPARα and related molecules in the livers of mice with diet-induced NASH.

2017-03-21 | GSE93819 | GEO

Salicylic acid treatment and overexpression of a novel polyamine transporter gene for astaxanthin production in Phaffia rhodozyma

Project description:Phaffia rhodozyma is an ideal microbial astaxanthin resource. However, the low productivity of astaxanthin in this yeast obstructs the process of industrial production. Although P. rhodozyma is isolated from plant material and the phytohormone has proved to be an effective stimulator for microbial production, the effects and mechanisms of phytohormones on astaxanthin synthesis in P. rhodozyma have been rarely reported. In this study, a concentration of down to 0.5 mg/L exogenous salicylic acid (SA) could promote biomass, astaxanthin content and yield by 20.8%, 95.8% and 135.3% in P. rhodozyma, respectively. Further transcriptomic analysis showed that SA could discriminate well the transcriptomic profile of P. rhodozyma cells. The differently expressed genes (DEGs) in P. rhodozyma cells between the SA-treatment and the SA-free groups were identified, and involved in astaxanthin and its competitive metabolite synthesis, material supply, biomolecules metabolism and transportation, anti-stress and signal transductions at a global-cell level. A regulation mechanism of astaxanthin synthesis induced by SA, including perception and transduction of the SA signal, expression regulations of the downstream genes by transcription factors, and cellular stress response to the SA, is put forward in this study. The polyamine transporter gene (PT), as an up-regulated DEG, was overexpressed in the P. rhodozyma to obtain the transformant Prh-PT-006. It was found that biomass, astaxanthin content and yield of the Prh-PT-006 under 0.5 mg/L SA treatment could reach 6.6 g/L, 0.35 mg/g DCW and 2.3 mg/L, 24.5%, 143.1% and 199.0% higher than the wild strain at the SA-free condition, respectively. The result will provide the engineering targets for constructing strains with high-yield of astaxanthin, and help to accelerate the industrialization process of microbial astaxanthin.

2023-10-16 | GSE242572 | GEO

Comparative metabolic and transcriptomic analysis of macrozoids and palmelloid cells of Haematococcus pluvialis related to astaxanthin accumulation

Project description:In this work, we propose a metabolomic and transcriptomic comparative study between a vegetative state and intermediate reddish palmelloid state growing in continuous culture conditions, giving rise to a profound understanding of the first steps of the adaptation of Haematococcus pluvialis to nitrogen limitation and the correlation with astaxanthin biosynthesis. In addition, other related metabolic pathways as fatty acid biosynthesis, starch accumulation, citric acid cycle, and amino acid biosynthesis have been analyzed. Understanding the molecular basis of astaxanthin accumulation will be useful for the optimization of astaxanthin production.

2021-04-07 | GSE161337 | GEO

Transcriptome analysis in Haematococcus pluvialis: astaxanthin induction by salicylic acid (SA) and jasmonic acid (JA)

Project description:Haematococcus pluvialis transcriptome analysis The genetic transcriptome details of astaxanthin biosynthesis were analysed by exposing the algal cells to 25 mg/L of SA and JA for 1, 6 and 24 hours, plus to the control (no stress). SRP062153 PRJNA292140

2016-02-15 | E-GEOD-71986 | biostudies-arrayexpress

Leptin responsive neurons

Project description:Leptin responsive neurons

| PRJNA439388 | ENA

Leptin microbiome

Project description:microbiome of leptin deficient mice

| PRJEB52090 | ENA

Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action

Project description:We employed translating ribosome affinity purification followed by RNA sequencing to isolate and analyze mRNA from the hypothalamic LepRb neurons of wild-type or leptin-deficient (Lepob/ob) mice treated with vehicle or exogenous leptin. Although the expression of most of the genes encoding the neuropeptides commonly considered to represent the main targets of leptin action were altered only following chronic leptin deprivation, our analysis revealed other transcripts that were coordinately regulated by leptin under multiple treatment conditions. Among these, acute leptin treatment increased expression of the transcription factor Atf3 in LepRb neurons.

2020-12-03 | GSE162603 | GEO

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