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Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

ABSTRACT: Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

PROVIDER: PRJNA420492 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6334030.fastq.gz	Fastqsanger.gz
	SRR6334040.fastq.gz	Fastqsanger.gz
	SRR6334050.fastq.gz	Fastqsanger.gz
	SRR6334060.fastq.gz	Fastqsanger.gz
	SRR6334070.fastq.gz	Fastqsanger.gz

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Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.

Project description:BACKGROUND:Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts molecular responses. Herein, we examine the responses of two key molecular markers of dietary stress, namely variant-specific methylation at ribosomal DNA (rDNA) and small RNA distribution, including tRNA fragments, in a mouse model of protein restriction (PR) with exposure at pre- and/or post-weaning. RESULTS:We first confirm that pre-weaning PR exposure modulates the methylation state of rDNA in a genotype-dependent manner, whereas post-weaning PR exposure has no such effect. Conversely, post-weaning PR induces a shift in small RNA distribution, but there is no effect in the pre-weaning PR model. Intriguingly, mice exposed to PR throughout their lives show neither of these two dietary stress markers, similar to controls. CONCLUSIONS:The results show that the timing of the insult affects the nature of the molecular response but also, critically, that 'matching' diet exposure either side of weaning eliminates the stress response at the level of rDNA methylation and small RNA in sperm.

| S-EPMC5930764 | biostudies-literature

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-04-09 | GSE107541 | GEO

Transcript profiles in longissimus dorsi muscle and subcutaneous adipose tissue: A comparison of pigs with different post-weaning growth rates.

Project description:The objective of this experiment was to use transcriptional profiling of skeletal muscle and adipose tissue to develop a better understanding of the metabolic basis for poor weaned-pig transition. A total of 1,054 pigs were reared in commercial conditions and weighed at birth, weaning, and 3 weeks post- weaning. Transition average daily gain (tADG) was calculated as the average daily gain for the 3-week period post-weaning. Nine pigs from each of the lowest 10th percentile (low tADG) and the 60th-70th percentile (high tADG) were harvested at 3 weeks post-weaning. Differential expression analysis was conduced in both tissues using RNA-Seq methodology

2015-02-25 | GSE65983 | GEO

Transcript profiles in longissimus dorsi muscle and subcutaneous adipose tissue: A comparison of pigs with different post-weaning growth rates.

2015-02-25 | E-GEOD-65983 | biostudies-arrayexpress

Post weaning pig supplementation

Project description:Effect of post-weaning glutamine and/or milk supplementation on pig growth and intestinal development

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Metabolic adaptations to early life protein restriction differ by offspring sex and post-weaning diet in the mouse.

Project description:Low birth weight affects 1 in every 7 babies born globally and can predict a lifetime of increased risk for adverse health outcomes, including cardiovascular disease, hypertension, obesity, diabetes, and metabolic syndrome. Maternal low protein diet during pregnancy and lactation is a well-characterized rat model for low birth weight and the subsequent increase in chronic disease risk. However, mice have been relatively understudied in this paradigm and represent a critical resource for investigating the underlying molecular mechanisms that link adverse early life experience and the development of chronic disease.The present manuscript describes a mouse model of low birth weight (maternal consumption of low protein diet (8% protein) through pregnancy and lactation) and characterizes metabolic adaptations (food intake, locomotor activity, oxygen consumption, and glucose tolerance) in male and female offspring. At weaning, mice were maintained either on the control diet or a high fat diet. Notable sex differences were observed, with male mice from the low protein pregnancies showing increased food intake, hyperactivity and increased metabolic rate only when weaned to the high fat diet, while female mice consistently showed increased food intake and were hypometabolic, regardless of post-weaning diet.These data identify offspring sex and post-weaning diet as critical variables in the metabolic adaptations to early life protein deficiency, and suggest that females may be more vulnerable to the adverse long-term health consequences of low birth weight.

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small RNA-seq analysis of mouse sperm exposed to protein restriction during different critical time windows

Project description:Background: Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts the molecular response. Here we examine the responses of two key molecular markers of dietary stress – variant-specific methylation at ribosomal DNA (rDNA) and small RNA distribution including tRNA fragments – in a mouse model of protein restriction (PR) with exposures pre- and/or post-weaning. Results: We first confirm that pre-weaning PR exposure modulates the methylation state of rDNA in a genotype-dependent manner whereas post-weaning PR exposure has no such effect. Conversely, post-weaning PR induces a shift in small RNA distribution, but there is no effect in the pre-weaning PR model. Intriguingly, mice exposed to PR throughout their lives show neither of these two dietary stress markers, similar to controls.

2018-04-09 | GSE107539 | GEO

BisPCRSeq analysis of ribosomal DNA in mouse sperm exposed to protein restriction during different critical time windows

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Transcriptome in Rat Skeletal Muscle 1 month or 3 months after Early Protein Restriction

Project description:In the present study, we designed a 1-month protein restriction model using post-weaning rats, followed by a 2-month rebound feeding, to investigate how early life protein restriction affects overall body growth and muscle development, and whether these influences could be corrected by the following rebound feeding. Transcriptome profiling reveal that myogenic differentiation functions are upregulated while protein catabolism are downregulated as compensatory toward protein restriction, while endo-plasmic reticulum stress are enhanced, inducing undesired apoptosis.

2022-12-28 | GSE211928 | GEO

Partial replacement of glucose with galactose in the post-weaning diet positively affects markers of liver health

Project description:Previous research showed a beneficial programming effect of replacting glucose in the post-weaning diet with galactose on later life adiposity. Here, we studied the direct effect of the diets in the postweaning phase in female mice. In this study, female mice were fed a glucose diet (32 en% glucose; GLU) or a glucose+galactose diet (16 en% glucose and 16 en% galactose; GLU+GAL) postweaning for three weeks, from postnatal day (PN) 21 till PN42. We observed lower circulating insulin levels and lower hepatic triglyceride levels in the females on the GLU+GAL diet. The body weight, fat mass, liver weight and liver glycogen content did not differ between the groups. We next studied hepatic gene expression profiles, because of the altered hepatic triglyceride levels and since the liver is considered the primary site of galactose metabolism. However, detailed analyses including pathway analysis, showed mainly inflammation being reduced by the GLU+GAL treatment. This was confirmed by qPCR of liver tissues and focussed serum protein analysis.

2019-12-27 | GSE124929 | GEO

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