Project description:Genome wide DNA methylation profiling in the blood between Pulmonary tuberculosis patient's and normal people's who have genetic relationship wtih each other.
Project description:To search the methylation of genes which were associated with tuberculosis infecion We used the microarrays to detail the methylation of gDNA between with the tuberculosis infection and without the tuberculosis in monozygous twins
Project description:To search the genes which were associated with tuberculosis infecion We used the microarrays to detail the global programme of gene exprssion between with the tuberculosis infecion and without the tuberculosis in monozygous twins
Project description:: Pulmonary tuberculosis (TB) generates chronic systemic inflammation and metabolic dysregulation. The liver is the master regulator of metabolism and to determine the impact of pulmonary TB on this organ we undertook unbiased mRNA and protein analyses of the liver in mice with TB.
Project description:Pulmonary tuberculosis is a multigene disease, and some of the genes affect the development of Pulmonary tuberculosis. The study wants to find different expression genes in blood from Pulmonary tuberculosis patient and normal people who have genetic relationship wtih each other. We used microarrays to detail the global programme of gene expression in the blood between Pulmonary tuberculosis patient's and normal people's who have genetic relationship wtih each other.
Project description:Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci reponsible for the phenotypical differences. We performed comprehensive DNA methylation analysis in monozygotic twins manifesting differences in IQ scores. Genes with significantly different methylation status are considered as candidates related to human intelligence.