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Global transcriptional changes in U87MG glioblastoma cells upon shRNA-mediated TRIM52 knockdown

ABSTRACT: Global transcriptional changes in U87MG glioblastoma cells upon shRNA-mediated TRIM52 knockdown

PROVIDER: PRJNA421947 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6366260.fastq.gz	Fastqsanger.gz
	SRR6366253.fastq.gz	Fastqsanger.gz
	SRR6366254.fastq.gz	Fastqsanger.gz
	SRR6366255.fastq.gz	Fastqsanger.gz
	SRR6366256.fastq.gz	Fastqsanger.gz

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Global transcriptional changes in U87MG glioblastoma cells upon shRNA-mediated TRIM52 knockdown

Project description:shRNA-mediated ablation of the RING-finger protein TRIM52 from multiple glioblastoma cell lines reduces proliferation and tumorigenesis. To identify gene signatures underlying this phenomenon, transcritional profile of TRIM52 knockdown cells was compared to control cells. Upon TRIM52 ablation, we find 278 differentially regulated genes. Gene ontology analysis reveals that many of the upregulated genes are associated with glycolysis and biosynthetic processes.

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Transcriptome analysis of CD133 overexpressed U87MG glioblastoma cells

Project description:This study investigated the biological function of CD133 by ectopic expression of CD133 in U87MG cell line. Although CD133 is widely used as a cancer stem cell marker, there are a few studies that examined its own biological functions. While a number of loss-of-function studies about CD133 have shown that CD133 have effects on cancer progression, there are few gain-of-function studies about functions of CD133. Thus, we identified the potential function of CD133 by its overexpression in U87MG glioblastoma cell line. Though there were no significant changes in cell growth and sphere forming ability, elevated IL-1β and its downstream chemokines (CCL3, CXCL3, CXCL5) may function as chemoattractants which affect recruitment of Ly6G+ neutrophils surrounding necrotic regions in vivo and migration of neutrophil-like dHL-60 cells. Taken together, this results imply that CD133 can regulate IL-1β signaling, and promotes the environmental change.

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Gene expression data in U87MG cell line transfected with miR-490 overexpression vector PC-490 or its control PCDNA3.1 (+).

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