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Epigenetic control of genes and transposable elements

ABSTRACT: Epigenetic control of genes and transposable elements

PROVIDER: PRJNA422428 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6376840_1.fastq.gz	Fastqsanger.gz
	SRR6376840_2.fastq.gz	Fastqsanger.gz
	SRR6376850_1.fastq.gz	Fastqsanger.gz
	SRR6376850_2.fastq.gz	Fastqsanger.gz
	SRR6376860_1.fastq.gz	Fastqsanger.gz

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Epigenetic control of genes and transposable elements [ATAC-seq]

Project description:Epigenetic control is an elaborate system the cell uses to control aspects of cell type and gene control. Histones and DNA are chemically modified to signal epigenetic information as to whether a gene is active or inactive, and so maintain cell type stability. Whilst epigenetic control of genes has been explored, the control of the rest of the genome is less well explored. The bulk of DNA and chromatin consists of repetitive elements, not genes, and these TEs must be tightly regulated to provide structure and function for nearby genes and, ultimately, cell type control. In this project we explore the intereaction of epigenetic control factors, and inhibitors, and how perturbation of the epigenetic control system disrupts TE regulation inside embryonic stem cells.

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Epigenetic control of transposable elements in the mouse male germ line by Tex15

Project description:The piRNA biogenesis was evaluated in the mouse testes lacking TEX15. Total small RNAs, MILI-, and MIWI2-associated small RNAs from control (Tex15+/-) and Tex15(-/-) knock-out testes were sequenced. Data analysis revealed that the abundance of miRNAs and piRNAs was comparable between control and Tex15 knock-out testes, suggesting that loss of TEX15 function does not impair piRNA biogenesis. However, the relative abundance of MILI- and MIWI2-bound sense piRNAs derived from transposable elements was increased.

2020-11-27 | GSE107832 | GEO

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