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Gene expression profiling of T cells of CLL patients, stimulated with antiCD3 antibody in presence or not of idelalisib

ABSTRACT: Gene expression profiling of T cells of CLL patients, stimulated with antiCD3 antibody in presence or not of idelalisib

PROVIDER: PRJNA422875 | ENA |

REPOSITORIES: ENA

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Gene expression profiling of T cells of CLL patients, stimulated with antiCD3 antibody in presence or not of idelalisib

Project description:The aim of the study is to identify genes modulated by idelalisib in T cells of CLL patients, that could suggest an impairment of T cell-mediated immunity caused by the drug. We found 61 genes downregulated by idelalisib in stimulated T cells with Anova p≤0.01 and [FC]≥2 and the most represented categories were chemokines involved in T cell migration (as CXCL9-10-11), inflammatory and T helper cytokines (as IL-2, TNFα, IFNg, IL-13, IL-21), mitogenic signal transducers (as IRF4, STAT1, EGR1-2-3-4) and receptors (as CD69, CD25) commonly induced during activation of T cells.

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Gene expression data from primary human hepatocytes treated with idelalisib for 24 h

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Expression data from healthy and malignant (chronic lymphocytic leukemia, CLL) human B-lymphocytes after B-cell receptor stimulation

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Expression data from healthy and malignant (chronic lymphocytic leukemia, CLL) human B-lymphocytes after B-cell receptor stimulation

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