Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq SER_Meth]

ABSTRACT: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq SER_Meth]

PROVIDER: PRJNA423285 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6398790.fastq.gz	Fastqsanger.gz
	SRR6398791.fastq.gz	Fastqsanger.gz
	SRR6398782.fastq.gz	Fastqsanger.gz
	SRR6398792.fastq.gz	Fastqsanger.gz
	SRR6398783.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_Meth]

Project description:A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_Meth]

| PRJNA423284 | ENA

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_6-OHDA]

Project description:A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_6-OHDA]

| PRJNA423283 | ENA

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_Meth]

Project description:The adult brain is composed of hundreds of different neuronal subtypes, which retain their differentiated traits and identity throughout the lifespan of the organism. Nevertheless, in part due to technical limitations, the mechanisms governing this stability are not fully understood. Here, using a strategy that allows for ChIP-seq combined with RNA-seq in sparse neuronal populations in vivo, we present, to our knowledge, the first comparative analysis of permissive and repressive histone modifications in adult midbrain dopaminergic neurons, raphe nuclei serotonergic neurons and embryonic neural progenitors. Our results support a model wherein a sequential deposition of the repressive modifications H3K27me3 and H3K9me3 occur on developmental genes in a neuronal subtype specific manner. We furthermore show that aberrant gene expression during dopaminergic stress in a mouse model of Parkinson’s disease, or after methamphetamine injection, is characterized by the de-repression of genes with promoter regions that are dually marked by H3K4me3 and H3K27me3, whereas the induction of genes with promoter regions marked by any other combination of H3K27me3 and H3K9me3 occur less frequently. Our study provides to our knowledge the first genome-wide analysis of permissive/repressive histone modifications coupled to gene expression in these rare but clinically relevant neuronal subtypes. This strategy can be generalized for the identification and functional characterization of molecular determinants involved in the maintenance of gene expression in other classes of neurons.

2018-01-25 | GSE108371 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq SER_Meth]

2018-01-25 | GSE108372 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [TRAP-Seq mDA_6-OHDA]

2018-01-25 | GSE108370 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

Project description:A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

| PRJNA420978 | ENA

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [RNA-Seq]

2018-01-25 | GSE107655 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [ChIP-Seq]

2018-01-25 | GSE107309 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [scRNA-Seq]

2018-01-25 | GSE107740 | GEO

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [RNA-Seq]

Project description:A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons [RNA-Seq]

| PRJNA420984 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data