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Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA array]

ABSTRACT: Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA array]

PROVIDER: PRJNA427131 | ENA |

REPOSITORIES: ENA

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Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease

Project description:Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease

| PRJNA427123 | ENA

Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA-seq]

Project description:Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA-seq]

| PRJNA427129 | ENA

Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA array]

Project description:Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the CAG expansion in the Huntingtin (HTT) gene. Several studies have shown the potential of microRNAs as biomarkers in neurodegenerative diseases. However, no bona fide microRNAs have been identified as promising diagnostic biomarkers for HD. As part of the PREDICT-HD project, here we performed NanoString on blood samples of 115 pre-manifest HD cases and 111 controls in an effort to provide promising biomarkers for the diagnostic of HD or the disease processes tracking. The results showed that five miRNAs (miR-1252, miR-433, miR-553, miR-138-5p and miR-2053) are significantly differentially expressed in pre-manifest gene-positive HD cases vs. gene-negative controls. We also explored the miRNAs associated with HD severity by correlating the miRNA expression with CAP scores of 115 pre-manifest HD samples and found that 41 and 24 miRNAs are negatively and positively correlated with CAP scores significantly. Furthermore, target gene set of miR-138 and miR-433 , its co-expressed mRNAs in ROSMAP, and differentially expressed mRNAs of HD reveal four overlap genes (CASP7, CNOT6L, TMED and FERMT2). In summary, our study provides new insights into biomarker of Huntington’s disease by analyzing the cross-sectional miRNA expression data in blood.

2018-06-19 | GSE108395 | GEO

RNA-seq of micro RNAs (miRNAs) in Human prefrontal cortex to identify differentially expressed miRNAs between Huntington's Disease and control brain samples

Project description:To identify genome-wide differentially expressed microRNAs (miRNAs) between Huntington's disease (HD) and control Human pre-frontal cortex samples

2014-01-30 | E-MTAB-2206 | biostudies-arrayexpress

Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease [miRNA-seq]

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Differential expression analysis of miRNAs expressed in blood and CSF of Huntington's disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-19 | GSE108398 | GEO

RNA-seq of micro RNAs (miRNAs) in Human prefrontal cortex to identify differentially expressed miRNAs between Huntington's Disease and control brain samples

Project description:RNA-seq of micro RNAs (miRNAs) in Human prefrontal cortex to identify differentially expressed miRNAs between Huntington's Disease and control brain samples

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Differentially expressed miRNAs in colorectal cancer

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Expression profile of miRNAs in PBMCs infected with CSF vaccine virus in six crossbred pigs

Project description:Using high-throughput technology, we aim to identify the expression of miRNAs for understanding the pathogenesis of CSF vaccine virus.

2018-05-14 | GSE114377 | GEO

University of Washington CSF biomarker study for Parkinson disease

Project description:<p>There is a clear need to develop biomarkers for Parkinson disease (PD) diagnosis and monitoring disease progression. In this study we evaluated cerebrospinal fluid (CSF) proteins, which are known to be critically involved in PD or identified in our preliminary profiling studies, aptamers, and RNAs as potential PD biomarkers. Access to subjects for this study was via the Pacific Northwest Udall Center (PANUC) and the Alzheimer's Disease Research Center (ADRC) at the University of Washington and Oregon Health and Sciences University (OHSU). Using CSF samples from 30 well-characterized patients with PD and 30 age-, sex-matched healthy controls, we prepared RNA seq libraries and performed deep sequencing of all RNA species, including small and long RNA, mRNAs, noncoding RNAs and differentially spliced transcripts. We then tried several methods for RNAseq data analysis to optimize our analysis pipeline. We identified a total of 3381 transcripts corresponding to 182 long intergenic RNAs (LincRNAs), 11 microRNAs (miRNAs), 2861 protein-coding transcripts, 200 pseudogenes and 127 antisense RNAs; some of them were differentially expressed between PD and control groups. Selected differentially expressed RNAs have been validated in the same set of CSF samples using real-time PCR (RT-PCR). Further validations in independent, larger cohorts of samples are still ongoing. Our results obtained so far suggested that CSF proteins and RNAs could be used as good indexes for PD diagnosis and disease severity/progression. This study is a part of the NIDDS-funded Parkinson's Disease Biomarkers Program (PDBP).</p>

| phs000901 | dbGaP

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