Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Isolated Iliac Cryptococcosis in an Immunocompetent Patient

ABSTRACT: Isolated Iliac Cryptococcosis in an Immunocompetent Patient

PROVIDER: PRJNA427575 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6420476_1.fastq.gz	Fastqsanger.gz
	SRR6420476_2.fastq.gz	Fastqsanger.gz
	SRR6420477_1.fastq.gz	Fastqsanger.gz
	SRR6420477_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Isolated Iliac Cryptococcosis in an Immunocompetent Patient

Project description:Cryptococcal osteomyelitis is an infrequent infection which is usually associated with disseminated cryptococcosis or underlying immunocompromised conditions. Here we described a rare case with isolated iliac cryptococcosis in an immunocompetent patient. Through histological, microbial, and molecular biological examinations, the pathogen was finally identified as C. neoformans VNI genotype, which likely originated from environmental bird droppings. The clinical isolate was hypomelanized but fully virulent in mouse infection model. The patient displayed lower CD4+-T lymphocyte ratio, reduced serum IFN-γ and IL-12, and dysregulated transcriptional profile of blood leukocytes compare with healthy host. After surgical excision and 34 weeks’ antifungal treatment, the patient got clinical cured. Our study suggested that cryptococcosis development was closely associated with the interaction of fungal agent and host immunity. Accurate diagnosis of bone cryptococcosis depends mainly on histological and fungal examinations. A combination of antifungal agent treatment regimen and surgery were quite effective for resolving bone cryptococcosis.

2018-04-17 | GSE108534 | GEO

Isolated iliac cryptococcosis in an immunocompetent patient.

Project description: Not available

| S-EPMC5875738 | biostudies-literature

Helicobacter pylori strain:isolated from patient | isolate:isolated from patient

Project description:Helicobacter pylori strain:isolated from patient | isolate:isolated from patient Genome sequencing

| PRJNA393647 | ENA

Mycotic aneurysm caused by Helicobacter cinaedi in an immunocompetent patient

Project description:Mycotic aneurysm caused by Helicobacter cinaedi in an immunocompetent patient

| PRJEB42769 | ENA

Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome

Project description:Paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome

2019-01-29 | GSE108649 | GEO

Metagenomic Next-Generation Sequencing in diagnosis of Talaromycosis of an immunocompetent patient

Project description:Metagenomic Next-Generation Sequencing in diagnosis of Talaromycosis of an immunocompetent patient

| PRJEB43434 | ENA

Pleural cryptococcosis diagnosed by pleural biopsy in a thymoma patient: a case report

Project description:Pleural cryptococcosis diagnosed by pleural biopsy

| PRJEB64498 | ENA

Vascularized immunocompetent patient-derived tumor model to predict treatment response for lung cancer patients

Project description:Vascularized immunocompetent patient-derived tumor model to predict treatment response for lung cancer patients

| PRJNA1004587 | ENA

Microevolution of Cryptococcus neoformans in high CO2 converges on mutations isolated from patients with relapsed cryptococcosis

Project description:Microevolution of Cryptococcus neoformans in high CO2 converges on mutations isolated from patients with relapsed cryptococcosis

| PRJNA1200720 | ENA

Microevolution of Cryptococcus neoformans in high CO2 converges on mutations isolated from patients with relapsed cryptococcosis

Project description:Cryptococcus neoformans is an environmental fungus that causes an estimated 180,000 deaths annually and transitions from the external environment to the host environment to cause disease. CO2 concentrations in the atmosphere (0.04%) are dramatically lower than in mammalian tissues (5%). Environmental C. neoformans strains that cannot tolerate 5% CO2 are much less virulent than CO2-tolerant strains. Microevolution at elevated CO2generated loss-of-function mutations in the nucleotide binding protein Avc1 that confer CO2 tolerance to CO2-intolerant strains. Mechanistically, Avc1 positively regulates the expression of plasma membrane transporters including PDR9, a phospholipid floppase that negatively modulates CO2 fitness. Deletion of AVC1 in five CO2-intolerant environmental strains increased competitive fitness in host CO2 and in a mouse infection model. Importantly, strains with similar AVC1 mutations have emerged in patients with relapsed cryptococcosis. Therefore, this microevolutionary convergence strongly suggests that adaptation to host CO2 is a significant driver of C. neoformans fitness during infection.

2025-02-24 | GSE284927 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data