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Transcriptional profiling of HT-29 cells with different treatments

ABSTRACT: Transcriptional profiling of HT-29 cells with different treatments

PROVIDER: PRJNA427878 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6429240.fastq.gz	Fastqsanger.gz
	SRR6429241.fastq.gz	Fastqsanger.gz
	SRR6429242.fastq.gz	Fastqsanger.gz
	SRR6429243.fastq.gz	Fastqsanger.gz
	SRR6429244.fastq.gz	Fastqsanger.gz

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Project description:Through RNA-seq, we investigated the transcriptional changes of necroptotic cell induced by TNF-α, SM-164 and zVAD. We report here that necroptosis leads to transcriptional activation of a large set of genes including pro-inflammatory cytokines, which is much stronger than that triggered by TNF-α alone. Furthermore, the robust induction of cytokine expression could be blocked by necroptotic inhibitor Nec-1s. Thus, we show that necroptosis exerts a profound effect on transcription, and activate the expression of pro-inflammatory genes, providing insights into the mechanism by which necroptosis promotes inflammation in human diseases.

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