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Elevated mTOR signaling increases the expression of lysosome genes, but does not alter the expression of inflammatory profiles of microglia as evaluated by low input RNAseq analysis.

ABSTRACT: Elevated mTOR signaling increases the expression of lysosome genes, but does not alter the expression of inflammatory profiles of microglia as evaluated by low input RNAseq analysis.

PROVIDER: PRJNA427905 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6429840.fastq.gz	Fastqsanger.gz
	SRR6429841.fastq.gz	Fastqsanger.gz
	SRR6429842.fastq.gz	Fastqsanger.gz
	SRR6429843.fastq.gz	Fastqsanger.gz
	SRR6429836.fastq.gz	Fastqsanger.gz

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Elevated mTOR signaling increases the expression of lysosome genes, but does not alter the expression of inflammatory profiles of microglia as evaluated by low input RNAseq analysis.

Project description:The RNA-seq data was generated to evaluate the efforts of elevated mTOR signaling on the inflammatory transcriptome in the mouse microglia. Our data shows that there were no significant differences in expression levels of major proinflammatory cytokines, chemokines and inflammatory mediators. However, there was a significant induction of lysosome genes, along with up- or down-regulation of genes involved in phagocytosis in TSC1 knockout microglia.

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Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection

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Enhanced and selective translation expands the lysosome size and promotes antigen presentation during phagocyte activation

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