Multi-omics profiling for individualized precision wellness
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA428253 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR6435710_1.fastq.gz | Fastqsanger.gz | |||
| SRR6435710_2.fastq.gz | Fastqsanger.gz | |||
| SRR6435720_1.fastq.gz | Fastqsanger.gz | |||
| SRR6435720_2.fastq.gz | Fastqsanger.gz | |||
| SRR6435730_1.fastq.gz | Fastqsanger.gz |
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Project description:"The investigation includes findings from our clinical trial, monitoring individualized response to pneumococcal vaccination, where we have carried out integrative profiling on peripheral blood mononuclear cells (PBMCs) and saliva pre and post vaccination. This is to our knowledge the most extensive saliva-centered omics dataset on an individual, covering more than 100 timepoints over the course of one year. The time span covers a healthy period as well as comprehensive monitoring of innate and adaptive immune responses following pneumococcal vaccination. Protein and RNA from saliva and PBMCs were extracted at various timepoints (100+ timepoints for saliva, 25 for PBMCs), and mass spectrometry proteomics and RNA-sequencing were carried out for all samples in non-targeted comprehensive profiling.
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