Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Developmental history provides a roadmap for the emergence of tumor plasticity

ABSTRACT: Developmental history provides a roadmap for the emergence of tumor plasticity

PROVIDER: PRJNA429224 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6453160.fastq.gz	Fastqsanger.gz
	SRR6453161.fastq.gz	Fastqsanger.gz
	SRR6453162.fastq.gz	Fastqsanger.gz
	SRR6453154.fastq.gz	Fastqsanger.gz
	SRR6453155.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.

Project description:We show that the loss or gain of transcription factor programs that govern embryonic cell-fate specification is associated with a form of tumor plasticity characterized by the acquisition of alternative cell fates normally characteristic of adjacent organs. In human non-small cell lung cancers, downregulation of the lung lineage-specifying TF NKX2-1 is associated with tumors bearing features of various gut tissues. Loss of Nkx2-1 from murine alveolar, but not airway, epithelium results in conversion of lung cells to gastric-like cells. Superimposing oncogenic Kras activation enables further plasticity in both alveolar and airway epithelium, producing tumors that adopt midgut and hindgut fates. Conversely, coupling Nkx2-1 loss with foregut lineage-specifying SOX2 overexpression drives the formation of squamous cancers with features of esophageal differentiation. These findings demonstrate that elements of pathologic tumor plasticity mirror the normal developmental history of organs in that cancer cells acquire cell fates associated with developmentally related neighboring organs.

| S-EPMC5875457 | biostudies-literature

Developmental history provides a roadmap for the emergence of tumor plasticity

Project description:Sox2 binding was assessed in lung epithelial cells, in the presence or absence of Nkx2-1.

2018-03-15 | GSE108952 | GEO

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

Project description:Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

| PRJNA1096710 | ENA

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

Project description:Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

| PRJNA1096712 | ENA

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

Project description:Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

| PRJNA1096244 | ENA

Roadmap Epigenomics Program - Broad

Project description:Roadmap Epigenomics Program - Broad

| PRJNA233641 | ENA

Roadmap Epigenomics Program - UCSF

Project description:Roadmap Epigenomics Program - UCSF

| PRJNA259584 | ENA

Activity-dependent history in hippocampal neurons dictates temporal dynamics of homeostatic synaptic scaling

Project description:Neural circuits utilize a host of homeostatic plasticity mechanisms, including synaptic scaling, to maintain stability in circuits undergoing experience-dependent remodeling necessary for information processing. During synaptic scaling, compensatory adaptations in synaptic strength are induced after chronic manipulations in neuronal firing, but our understanding of this process is largely limited to its initial induction. How these homeostatic synaptic adaptations evolve when activity renormalizes and their impact on subsequent homeostatic compensation are both poorly understood. To examine these issues, we investigated whether a previous history of homeostatic scaling in networks of cultured hippocampal neurons altered their subsequent homeostatic responses to chronic activity manipulations. Unexpectedly, we found that a history of synaptic scaling strongly suppressed future scaling to the same, and even opposite, activity challenges. This history-dependent suppression was specific for future homeostatic compensation, as networks with a prior scaling history showed no deficits in the chemical induction of long-term potentiation (cLTP), a Hebbian form of synaptic plasticity. Hippocampal neurons with a prior scaling history exhibited normal engagement of activity-dependent signaling during subsequent activity challenges (as assessed by examination of the ERK/MAPK pathway) but demonstrated widespread alterations in activity-dependent transcriptional

2024-09-01 | GSE180993 | GEO

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

Project description:Stem cell-based models of human heart tissue and cardiac differentiation employ monolayer and 3D organoid cultures with different properties, cell type composition, and maturity. Here we show how cardiac monolayer, embryoid body, and engineered heart tissue trajectories compare in a single-cell roadmap of atrial and ventricular differentiation conditions. Using a multiomic approach and gene-regulatory network inference, we identified regulators of the epicardial, atrial and ventricular cardiomyocyte lineages. We identified ZNF711 as a regulatory switch and safeguard for cardiomyocyte commitment. We show that ZNF711 ablation prevents cardiomyocyte differentiation in the absence of retinoic acid, causing progenitors to be diverted more prominently to epicardial and other lineages. Retinoic acid rescues this shift in lineage commitment and promotes atrial cardiomyocyte differentiation by regulation of shared and complementary target genes, showing an interplay between ZNF711 and retinoic acid in cardiac lineage commitment.

2025-01-27 | GSE263326 | GEO

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

2025-01-27 | GSE263325 | GEO