Project description:The different phases of tumor immunoediting in vivo were dissected thanks to a murine model of glioma induced by PDGF-B overexpression. We show that low-grade gliomas are highly immunostimulatory and that the adaptive immune system prevents the development of secondary tumor in syngeneic mice. During tumor progression, glioma cells downregulate immunostimulatory genes and the immune infiltrate becomes pro-tumorigenic. We showed that glioma cells are able to progress towards a high-grade phenotype even in immunodeficient mice, albeit more slowly and this progression invariably requires a downregulation of immunostimulatory genes.

2018-10-22 | GSE108955 | GEO

Expression data from PDGF-B and EGFRvIII induced murine gliomas

Project description:Expression data from PDGF-B and EGFRvIII induced murine gliomas

| PRJNA549941 | ENA

Expression data from PDGF-B and EGFRvIII induced murine gliomas

Project description:The trascription profiles of PDGF-B and EGFRvIII induced glioma models were compared. We show that both models converge towards a phenotype that resembles proneural glioblastoma subset.

2019-06-25 | GSE133095 | GEO

RNAseq analysis of murine brainstem gliomas with and without H3.3K27M

Project description:Using the RCAS/tv-a system, we induced murine brainstem gliomas (PDGF-B; p53 loss using RCAS-Cre with and without H3.3K27M) in Nestin tv-a; p53 floxed mice

2017-05-11 | GSE98765 | GEO

Expression data from PDGF-B induced murine gliomas transplanted in NOD/SCID mice

Project description:Expression data from PDGF-B induced murine gliomas transplanted in NOD/SCID mice

| PRJNA429239 | ENA

PDGF-B induces a homogeneous class of oligodendrogliomas from embryonic neural progenitors

Project description:We analyzed the generation of mouse gliomas following the overexpression of PDGF-B in embryonic neural progenitors. Comparison of our microarray data, with published gene expression data sets for many different murine neural cell types, revealed a closest relationship between our tumor cells and oligodendrocyte progenitor cells, confirming definitively that PDGF-B-induced gliomas are pure oligodendrogliomas.

2008-11-28 | GSE12836 | GEO

Expression data from PDGF-B induced murine gliomas at different stages and after transplantation

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-22 | GSE108956 | GEO

RNAseq of murine models of high-grade gliomas induced by overexpression of PDGF-B or EGFRvIII

Project description:RNAseq of murine models of high-grade gliomas induced by overexpression of PDGF-B or EGFRvIII

| PRJNA431534 | ENA