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Haematobia irritans

ABSTRACT: Transcriptome of the horn fly, Haematobia irritans

PROVIDER: PRJNA429442 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6659624_1.fastq.gz	Fastqsanger.gz
	SRR6659624_2.fastq.gz	Fastqsanger.gz
	SRR6659625_1.fastq.gz	Fastqsanger.gz
	SRR6659625_2.fastq.gz	Fastqsanger.gz
	SRR6659626_1.fastq.gz	Fastqsanger.gz

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Haematobia irritans

Project description:The horn fly is an obligate blood-feeding parasite of cattle

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Cryptocaryon irritans

Project description:Cryptocaryon irritans Transcriptome or Gene expression

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Rubus irritans

Project description:Rubus irritans overview

| PRJNA771751 | ENA

Comparative Transcriptome Analysis Reveals immunoregulation mechanism of lncRNA-mRNA in Large Yellow Croaker (Larimichthys crocea) in Response to Cryptocaryon irritans Infection

Project description:Cryptocaryonosis caused by Cryptocaryon irritans is one of the major diseases of large yellow croaker (Larimichthys crocea), which lead to massive economic losses annually. The pathogenesis for cryptocaryonosis has been researched by a series of transcriptome studies under different infection conditions. However, little is known about the roles of tissue-specifically expressed genes during the infection of C. irritans. In this study, we analyzed the tissue-specific expression of transcripts in the major infection organs including gill and skin of L. crocea after C. irritans infection. we constructed transcriptome expression profiles of L. crocea gill and skin, including 23,172 protein-coding genes and 7,503 long noncoding RNAs (lncRNAs). By comparing transcriptome data from different tissues of L. crocea, we observed tissue specificity of transcripts in gill and skin, including 3,003 protein coding genes and 639 lncRNAs. A total of 212 of the protein coding genes were involved in immune system. Further analysis revealed that the tissue-specific DEGs in gill and skin were mainly involved in HIF-1 signaling pathway and Complement and coagulation cascades, respectively. In addition, 9 non-tissue-specific hub genes, including CCL4, DDIT4, LEP, ect., which are highly associated with C. irritans infection were identified. To our knowledge, this is the first comparative transcriptome analysis of gill and skin after C. irritans infection. Our results are helpful to understand the molecular mechanism of pathogenesis for cryptocaryonosis, espec-tissue specificity of protein-coding genes and lncRNAs involved in immune regulation.

2021-11-28 | GSE174221 | GEO

Rubus irritans

Project description:Rubus irritans Genome sequencing

| PRJNA771538 | ENA

Functional genomics of the horn fly, Haematobia irritans (Linnaeus, 1758).

Project description:BACKGROUND: The horn fly, Haematobia irritans (Linnaeus, 1758) (Diptera: Muscidae) is one of the most important ectoparasites of pastured cattle. Horn flies infestations reduce cattle weight gain and milk production. Additionally, horn flies are mechanical vectors of different pathogens that cause disease in cattle. The aim of this study was to conduct a functional genomics study in female horn flies using Expressed Sequence Tags (EST) analysis and RNA interference (RNAi). RESULTS: A cDNA library was made from whole abdominal tissues collected from partially fed adult female horn flies. High quality horn fly ESTs (2,160) were sequenced and assembled into 992 unigenes (178 contigs and 814 singlets) representing molecular functions such as serine proteases, cell metabolism, mitochondrial function, transcription and translation, transport, chromatin structure, vitellogenesis, cytoskeleton, DNA replication, cell response to stress and infection, cell proliferation and cell-cell interactions, intracellular trafficking and secretion, and development. Functional analyses were conducted using RNAi for the first time in horn flies. Gene knockdown by RNAi resulted in higher horn fly mortality (protease inhibitor functional group), reduced oviposition (vitellogenin, ferritin and vATPase groups) or both (immune response and 5'-NUC groups) when compared to controls. Silencing of ubiquitination ESTs did not affect horn fly mortality and oviposition while gene knockdown in the ferritin and vATPse functional groups reduced mortality when compared to controls. CONCLUSIONS: These results advanced the molecular characterization of this important ectoparasite and suggested candidate protective antigens for the development of vaccines for the control of horn fly infestations.

| S-EPMC3045961 | biostudies-literature

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