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High-throughput sequencing identify miRNAs involved in exosomes of MDA-MB-231 cocultivated with or without mature 3T3-L1

ABSTRACT: High-throughput sequencing identify miRNAs involved in exosomes of MDA-MB-231 cocultivated with or without mature 3T3-L1

PROVIDER: PRJNA432230 | ENA |

REPOSITORIES: ENA

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	SRR6653346.fastq.gz	Fastqsanger.gz

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High-throughput sequencing identify miRNAs involved in exosomes of MDA-MB-231 cocultivated with or without mature 3T3-L1

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Gene expression profiles of human breast cancer cell lines MCF-7, T47D and MDA-MB-231 co-cultured with 3T3-L1 adipocytes.

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Project description:Dicer, RNase III endonuclease, is an essential enzyme in miRNA biogenesis that regulates target gene expression, and it has been reported that aberrant expressions of Dicer associate with the clinical outcomes of patients in various cancers. To explore the miRNA differencial expression regulated by Dicer in MDA-MB-231/E1A cells, the microarray profiling analysis was employed to conduct differentially expressed miRNAs in stable MDA-MB-231/vector, MDA-MB-231/E1A, and MDA-MB-231/E1A/shDicer cells.

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