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Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

ABSTRACT: Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

OTHER RELATED OMICS DATASETS IN: GSE110007

PROVIDER: PRJNA432548 | ENA |

REPOSITORIES: ENA

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Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome.

Project description:Genome wide DNA methylation profiling of human labial salivary gland (LSG) biopsy samples obtained from 28 female members of the Sjögren's International Collaborative Clinical Alliance (SICCA) Registry. The Illumina HumanMethylation450 BeadChip platform was used to obtain DNA methylation profiles across more than 450,000 highly informative CpG sites. Samples included 15 non-case glands, and 13 glands from patients with Sjögren's Syndrome.

2018-02-02 | GSE110007 | GEO

Development of gene expression signatures of liver in a primary Sjögren's syndrome mouse model

Project description:To elucidate gene expression signatures of liver induced by Sjögren's syndrome, we have employed whole genome microarray expression profiling as a discovery platform.

2023-12-11 | GSE249144 | GEO

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

Project description:While all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. To assess immunopathway activation in paired parotid and labial gland tissue from biopsy-positive and biopsy-negative pSS and non-SS sicca patients, paraffin-embedded, paired parotid and labial salivary gland tissue and peripheral blood mononuclear cells were obtained from 39 pSS and 20 non-SS sicca patients. The patients were subdivided based on fulfillment of ACR-EULAR criteria and histopathology and the samples were analyzed for differentially expressed genes (DEGs). The principal component analysis of SG gene expression could only separate biopsy-positive pSS from non-SS sicca patients. However, when comparing the transcriptome of biopsy-positive pSS and biopsy-negative non-SS sicca patients, 1235 and 624 DEGs (FDR<-1 or >1) were identified for parotid and labial glands, respectively. The number of DEGs between biopsy negative pSS and non-SS sicca patients was scarce. The overall, transcript expression levels correlated strongly between parotid and labial glands (R2=0.86, p‐value<0.0001). Gene signatures present in both glands of biopsy‐positive pSS patients included IFN‐α signaling, IL-12/IL-18 signaling, CD3/CD28 T-cell activation, CD40 signaling in B-cells, DN2 B-cells, and FcRL4+ B-cells. Signature scores varied considerably amongst pSS patients. In conclusion, the transcriptomes of paired major and minor SGs in pSS were overall comparable, although significant inter-individual heterogeneity in immunopathway activation existed. The SG transcriptome of biopsy-negative pSS was indistinguishable from non-SS sicca patients. The different patterns of SG immunopathway activation in pSS argue for personalized treatment approaches.

2022-07-16 | GSE208260 | GEO

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

2021-05-05 | GSE173808 | GEO

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

Project description:The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

| PRJNA727106 | ENA

The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

Project description:The transcriptome of paired major and minor salivary gland tissue in patients with primary Sjögren's syndrome

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LncRNA expression profile in minor salivary gland of Sjögren’s syndrome (SjS)

Project description:The present study was aimed to identify aberrantly expressed lncRNAs involved in the progression of SjS and explore their potential functions. Labial salivary gland of 4 SjS patients and 4 healthy controls was collected. LncRNA expression profile in labial salivary gland was analyzed by LncRNA microarray.

2015-12-16 | GSE76013 | GEO

Salivary gland during development and onset of xerostomia in murine model of Sjögren's syndrome-like disease

Project description:Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren’s syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the NOD mouse capable of conferring Sjögren’s syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice. In an attempt to define the molecular bases underlying onset of stomatitis sicca (xerostomia) in this C57BL/6.NOD-Aec1Aec2 mouse model, we have carried out a study utilizing microarray technology.

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Project description:Tumors of the major and minor salivary gland encompass a diverse spectrum of diagnostically challenging neoplasms. Recent studies have identified several gene fusions and somatic mutations that are specific or highly enriched in certain salivary gland tumor entities and can assist histopathological diagnosis. Still, there is an unmet need to identify additional diagnostic biomarkers for entities lacking specific alterations. In this study, we collected a comprehensive cohort of 363 cases encompassing 20 different salivary gland tumor entities and explored the potential of DNA methylation to classify these tumors. We were able to show that most entities show specific epigenetic signatures and present a machine learning algorithm that can be used to classify diagnostically challenging cases.

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Project description:The study aims to investigate the relevance of NKp30 receptor in the salivary glands inflammation of Sjogren’s syndrome patients in comparison to sicca patients (control group) analysing the transcriptomic profile of salivary gland tissues.

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