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LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response (AEC/LUAD RNA-seq data set)

ABSTRACT: LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response (AEC/LUAD RNA-seq data set)

PROVIDER: PRJNA432576 | ENA |

REPOSITORIES: ENA

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LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response (AEC/LUAD RNA-seq data set)

Project description:Lung cancer is the leading cause of cancer-related death in the United States. Long non-coding RNAs (lncRNAs) are a class of regulatory molecules whose role in lung carcinogenesis is poorly understood. In this study, we profiled lncRNA expression in lung adenocarcinoma (LUAD) cell lines, compared their expression to that of purified alveolar epithelial type II cells (the purported cell of origin for LUAD), cross-referenced these with lncRNAs altered in primary human tumors, and interrogated for lncRNA whose expression correlated with patient survival. We identified LINC00261, a lncRNA with unknown function in LUAD, adjacent to the pioneering transcription factor FOXA2. Loss of LINC00261 was observed in multiple tumor types, including liver, breast, and gastric cancer. Reintroduction of LINC00261 into human LUAD cell lines inhibited cell migration and slowed proliferation by inducing a G2/M cell cycle arrest while upregulating DNA damage pathway genes and inducing phosphorylation-mediated activation of components of the DNA damage pathway. FOXA2 was able to induce LINC00261 expression, and the entire locus underwent hypermethylation in LUAD, leading to loss of expression. We have thus identified an epigenetically deregulated lncRNA, whose loss of expression in LUAD promotes the malignant phenotype and blocks activation of the DNA damage machinery, predisposing lung cells to cancer development.

2019-03-01 | GSE110024 | GEO

LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response [H522-LINC00261 RNA-seq data set]

2019-03-01 | GSE110182 | GEO

LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response [H522-LINC00261 RNA-seq data set]

Project description:LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response [H522-LINC00261 RNA-seq data set]

| PRJNA433043 | ENA

Transcriptome analysis of influenza infected GFP+ AEC compared to bystander GFP- AEC

Project description:A GFP-expressing recombinant A/Puerto Rico/8/1934 influenza virus was used to infect C57BL/6 wild type mice and on day 3 post infection, lung alveolar epithelial cells (AEC) were isolated and sorted based on GFP expression. GFP+ AEC represent the infected AEC and GFP- AEC represent the bystander AEC. AEC were also sorted from uninfected mice to serve as controls.

2018-08-29 | GSE119123 | GEO

LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response

Project description:LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response

| PRJNA432574 | ENA

Disrupted transcriptional network in ΔNp63 AEC tissue model [ChIP-Seq]

Project description:The transcriptional basis for disrupted epidermal differentiation arising from TP63 AEC mutations remains to be elucidated. Here we present an organotypic model of AEC dysfunction that phenocopies differentiation defects observed in AEC patient skin. Transcriptional analysis of model AEC tissue revealed impaired induction of differentiation regulators, including OVOL1, GRHL3, KLF4, PRDM1 and ZNF750. Genome wide binding analyses of TP63 during epidermal differentiation showed direct binding of OVOL1, GRHL3, and ZNF750 promoters suggesting AEC mutants prevent normal activation of these targets by direct transcriptional interference. Remarkably, exogenous ZNF750 restores impaired epidermal differentiation caused by AEC mutation. Thus, repression of ZNF750 is central to disrupted epidermal differentiation in model AEC tissue.

2012-06-18 | GSE33571 | GEO

Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression]

2012-06-18 | GSE33495 | GEO

Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression]

2012-06-17 | E-GEOD-33495 | biostudies-arrayexpress

Disrupted transcriptional network in ΔNp63 AEC tissue model [ChIP-Seq]

2012-06-18 | E-GEOD-33571 | biostudies-arrayexpress

Disrupted transcripitonal network in ΔNp63 AEC tissue model

Project description:This SuperSeries is composed of the following subset Series: GSE33495: Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression] GSE33571: Disrupted transcriptional network in ΔNp63 AEC tissue model [ChIP-Seq] Refer to individual Series

2012-06-17 | E-GEOD-33572 | biostudies-arrayexpress

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