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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL-1]

ABSTRACT: Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL-1]

PROVIDER: PRJNA432776 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL-1]

Project description:KSHV-related primary effusion lymphoma is mostly seen in immunocompromised individuals such as HIV+ patients, who frequently suffering polymicrobial infections including different opportunistic pathogens. It is interesting to explore the host gene profile in PEL altered by bacterial quorum sensing molecules, the key systems regulating virulence factors in many bacteria.

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL_OdDHL]

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1_OdDHL]

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1]

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Altered global gene profile in KSHV+ PEL cells exposure to dhC16-Cer

Project description:Primary effusion lymphoma (PEL) is a rare B-cell malignancy that originates from B cells latently infected with Kaposi’s sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus-8, HHV8). Our previous data indicated that several exogenous ceramide and dh-ceramide species, such as C18-Cer and dhC16-Cer, also displayed effective anti-cancer activities for KSHV+ PEL in vitro and in vivo. However, the underlying mechanisms for exogenous ceramide “killing” PEL cells still require further investigation, which will be helpful to better understand PEL pathogenesis and identify more potential therapeutic targets. In the current study, we used Illumina microarray to determine the altered gene profile in KSHV+ PEL cell-line, BCBL-1 exposure to dhC16-Cer.

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules

Project description:Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules

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Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL_OdDHL]

Project description:Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL_OdDHL]

| PRJNA433007 | ENA

Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1]

Project description:Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1]

| PRJNA432775 | ENA

Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1_OdDHL]

Project description:Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCP-1_OdDHL]