Project description:SH3GL2 acts as a tumor suppressor. Our aim was to idenfy SH3GL2 regulatory pathways. We stably introduced SH3GL2 in SUM159 cells, exhibiting reduced cancer growth and pulmonary metastasis
Project description:RNA-sequencing was performed in SUM 159 parental and PTX resistant breast cancer cells in an effort to identify novel regulators of chemoresistance that could potentially be targeted in Triple Negative Breast Cancer (TNBC). The bioinformatic analysis identified numerous differentially expressed genes including several known chemoresistance markers, as well as novel genes that may play an important role in breast cancer chemoresistant cells.
Project description:Overexpression of Pierce1 in the breast cancer cell line SUM-159-PT (SUM) induced a higher resistance to anticancer drugs. To investigate the molecular basis of this chemoresistance, SUM cells overexpressing human Pierce1 (SUM-Pierce1) were compared to control cells (SUM-CTLR).
Project description:RNA-sequencing for the characterization of the transcriptome of SUM 159 parental and Paclitaxel (PTX) resistant breast cancer cells.