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Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 2]

ABSTRACT: Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 2]

PROVIDER: PRJNA433866 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6710660_1.fastq.gz	Fastqsanger.gz
	SRR6710660_2.fastq.gz	Fastqsanger.gz
	SRR6710661_1.fastq.gz	Fastqsanger.gz
	SRR6710661_2.fastq.gz	Fastqsanger.gz
	SRR6710656_1.fastq.gz	Fastqsanger.gz

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Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 1]

Project description:Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 1]

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Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 2]

Project description:Human endogenous retrovirus (HERV) genes were incorporated into the genome over millions of years but they mostly have inactivating mutations. HERV-K is the most recently incorporated virus. Incidental HERV-K gene expression occurs in a variety of pathological conditions. However, its physiological role is poorly understood. To study the role of HERV-K in development, we monitored its expression and function in pluripotent stem cells and during the process of neuronal differentiation. The expression of HERV-K env was localized to chromosomes 12 and 19. HERV-K Env was expressed on the cell surface of pluripotent stem cells and was critical in maintaining the stemness and adhesion of the cells. Interactions with CD98HC resulted in activation of signaling pathways that regulate stem cells genes. Down regulation of HERV-K env resulted in dissociation of the stem cell colonies and enhanced differentiation along neuronal pathways. HERV-K env expression during neurodevelopment was regulated by DNA methylation. Thus, HERV-K regulation is critical for human embryonic and neurodevelopment.

2020-08-05 | GSE110497 | GEO

Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 1]

Project description:Human endogenous retrovirus (HERV) genes were incorporated into the genome over millions of years but they mostly have inactivating mutations. HERV-K is the most recently incorporated virus. Incidental HERV-K gene expression occurs in a variety of pathological conditions. However, its physiological role is poorly understood. To study the role of HERV-K in development, we monitored its expression and function in pluripotent stem cells and during the process of neuronal differentiation. The expression of HERV-K env was localized to chromosomes 12 and 19. HERV-K Env was expressed on the cell surface of pluripotent stem cells and was critical in maintaining the stemness and adhesion of the cells. Interactions with CD98HC resulted in activation of signaling pathways that regulate stem cells genes. Down regulation of HERV-K env resulted in dissociation of the stem cell colonies and enhanced differentiation along neuronal pathways. HERV-K env expression during neurodevelopment was regulated by DNA methylation. Thus HERV-K regulation is critical for human embryonic and neurodevelopment.

2020-08-05 | GSE110267 | GEO

Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation

Project description:Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation

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Cryptic endogenous retrovirus subfamilies in the primate lineage

Project description:Cryptic endogenous retrovirus subfamilies in the primate lineage

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m6A methylation regulates the fate of endogenous retrovirus transcripts

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Project description:Germline piRNAs counteract endogenous retrovirus invasion from somatic cells

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Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

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Project description:The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses. In particular, Arc contains homology to the Gag polyprotein that forms the viral capsid and is essential for viral infectivity. This surprising connection raises the intriguing possibility that Arc may share molecular characteristics of retroviruses.

| S-EPMC5862763 | biostudies-literature

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