Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide effect of constitutive IFN-signaling

ABSTRACT: Genome-wide effect of constitutive IFN-signaling

PROVIDER: PRJNA434236 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6729611.fastq.gz	Fastqsanger.gz
	SRR6729612.fastq.gz	Fastqsanger.gz
	SRR6729613.fastq.gz	Fastqsanger.gz
	SRR6729614.fastq.gz	Fastqsanger.gz
	SRR6729615.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Genome-wide effect of constitutive IFN-signaling

Project description:Using wild type mice and mice deficient for either IFNb1 or IFN-receptor, we analysed the effect of the constitutive IFN on genome-wide expression

2018-06-01 | GSE110678 | GEO

Genome-wide effect of constitutive interferon on gene-expression

Project description:Using mice deficient for several genes that contribute to constitutive levels of type I interferon, we compared genome-wide expressionof RNA in rested macrophages of these mice.

2017-06-29 | GSE83885 | GEO

Constitutive active STING signaling in MC38 tumor cells

Project description:Constitutive active STING signaling in MC38 tumor cells

| PRJNA896150 | ENA

Effect of constitutive AHR activation in skeletal muscle

Project description:Effect of constitutive AHR activation in skeletal muscle

| PRJNA936613 | ENA

Transcription profiling of mouse wild type and Pias1 null cells in response to IFN treatments to study the effect of PIAS1 on interferon (IFN) signaling pathway

Project description:Microarray analysis was designed to study the effect of PIAS1 on interferon (IFN) signaling pathway by comparing the gene activation profiles of wild type and Pias1 null cells in response to IFN treatments. Microarray analysis was performed essentially following the manufacturer's instructions (Affymetrix). Briefly, bone marrow-derived macrophages (BMMs) from wile type or Pias1 null littermates were either untreated, or treated with IFN-beta (500 U/ml) or IFN-gamma (10 ng/ml) for 2h or 4h. Total RNA was prepared with RNA-STAT60 (TEL-TEST) and purified with the RNeasy kit (Qiagen). Double stranded complementary DNA was synthesized from 20 ug of total RNA according to Affymetrix methodology, and purified with Phase Lock Gels (Eppendorf). Biotin-labeled RNA was synthesized with the BioArray High Yield RNA Transcript Labeling Kit (Enzo). Samples were cleaned, fragmentated and hybridized to murine genome (MGU74Av2) Genechips (Affymetrix) as instructed. GeneChips were stained with phycoerythrin-streptavidin (Molecular Probes) and scanned with a GeneChip scanner (Affymetrix).

2007-10-10 | E-GEOD-1552 | biostudies-arrayexpress

Effect of constitutive AHR activation in skeletal muscle [AHRmKO_RNAseq]

Project description:Effect of constitutive AHR activation in skeletal muscle [AHRmKO_RNAseq]

| PRJNA937014 | ENA

IFN-λ signaling protects mice from severe HSV-1 skin disease II

Project description:Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought to define the skin-specific effects of IFN-λ against the highly prevalent human pathogen herpes simplex virus (HSV). We infected mice lacking the IFN-λ receptor (Ifnlr1-/-), both the IFN-λ and the IFN-αβ receptor (Ifnar1-/- Ifnlr1-/-), or IFN-λ cytokines (Ifnl2/3-/-) and found that IFN-λ restricts the severity of HSV-1 and HSV-2 skin lesions, independent of a direct effect on viral load. Using conditional knockout mice, we found that IFN-λ signaling in both keratinocytes and neutrophils was necessary to control HSV-1 skin lesion severity, and that IFN-λ signaling in keratinocytes suppressed CXCL9-mediated neutrophil recruitment to the skin. Furthermore, depleting neutrophils prevented the development of severe HSV-1 skin lesions in Ifnlr1-/- mice. Altogether, our results suggest that IFN-λ plays an immunomodulatory role in the skin that restricts neutrophil-mediated pathology during HSV infection, and suggest potential applications for IFN-λ in treating viral skin infections.

2023-09-12 | GSE242170 | GEO

IFN-λ signaling protects mice from severe HSV-1 skin disease I

2023-09-12 | GSE242068 | GEO

Constitutive active STING signaling in MC38 tumor cells [RNA-Seq]

Project description:Constitutive active STING signaling in MC38 tumor cells [RNA-Seq]

| PRJNA896153 | ENA

Constitutive active STING signaling in MC38 tumor cells [CITE-seq]

Project description:Constitutive active STING signaling in MC38 tumor cells [CITE-seq]

| PRJNA896152 | ENA