Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparing Wilms tumor primary samples to patient-derived xenografts

ABSTRACT: Comparing Wilms tumor primary samples to patient-derived xenografts

PROVIDER: PRJNA434302 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA methylation data comparing Wilms tumor primary samples to patient-derived xenografts

Project description:The lack of model systems limits the preclinical testing of novel therapies to address Wilms tumor patient groups with poor outcomes. Therefore, we established 45 heterotopic Wilms tumor patient-derived xenografts (WTPDX) in CB17 scid-/- mice that capture the biological heterogeneity of Wilms tumor (WT). These WTPDX include six showing diffuse anaplasia, nine from patients who went on to experience disease relapse, and thirteen from patients with bilateral disease. WTPDX retained the genetic alterations and the global transcriptomic and methylation profile of corresponding primary WT. In addition, favorable histology WTPDX were chemosensitive, while unfavorable histology WTPDX were resistant to conventional chemotherapy with vincristine, actinomycin-D, and doxorubicin. This WTPDX library is a unique scientific resource that retains the spectrum of biological heterogeneity present in WT and provides an essential tool for the testing of novel targeted therapies in the era of precision medicine.

2019-02-14 | GSE110697 | GEO

Gene expression data comparing Wilms tumor primary samples to patient-derived xenografts

2019-02-14 | GSE110696 | GEO

Gene expression data comparing Wilms tumor primary samples to patient-derived xenografts

Project description:Gene expression data comparing Wilms tumor primary samples to patient-derived xenografts

| PRJNA434301 | ENA

DNA methylation data comparing Wilms tumor primary samples to patient-derived xenografts

Project description:DNA methylation data comparing Wilms tumor primary samples to patient-derived xenografts

| PRJNA434304 | ENA

Comparing Wilms tumor primary samples to patient-derived xenografts

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-02-14 | GSE110699 | GEO

Expression data from patient and primary xenografts esophageal tumour samples

Project description:Microarrays were used to assess differences between 1) human tumours that did and did not engraft, 2) human tumours and their matched primary xenografts, 3) early and late passage primary xenografts and 4) small and large primary xenografts for a series of esophageal patient and primary xenograft tumours

2015-01-11 | GSE58870 | GEO

Thoracic patient-derived xenografts

Project description:Thoracic patient-derived xenografts

| PRJNA339191 | ENA

DNA copy number variation from human Wilms' Tumor samples

Project description:Genome-wide DNA copy number was studied to determine whether the Wilms' tumor samples generally show normal copy number variation comparing to the colon tumor samples We used custom Nimblegen microarrays to determine the genome-wide DNA copy number in human Wilms' Tumor samples

2011-08-29 | GSE29374 | GEO

Acute Myeloid Leukemia (AML) patient xenografts

Project description:Acute Myeloid Leukemia (AML) patient xenografts

| PRJNA736604 | ENA

RNA sequencing of Patient-Derived Xenografts

Project description:RNA sequencing of Patient-Derived Xenografts

| PRJNA1026533 | ENA