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Sequencing of Caenorhabditis elegans deletion mutants treated with RNAi

ABSTRACT: Sequencing of Caenorhabditis elegans deletion mutants treated with RNAi

PROVIDER: PRJNA434683 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6750840.fastq.gz	Fastqsanger.gz
	SRR6750841.fastq.gz	Fastqsanger.gz
	SRR6750842.fastq.gz	Fastqsanger.gz
	SRR6750843.fastq.gz	Fastqsanger.gz
	SRR6750834.fastq.gz	Fastqsanger.gz

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Sequencing of Caenorhabditis elegans deletion mutants treated with RNAi

Project description:Comparison of gene expression profiles from C. elegans mutant strain CF1038 treated with L4440 and K02A4.1 RNAi and C. elegans mutant strain TU3311 treated with L4440 and B0412.2 RNAi for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Sequencing of Caenorhabditis elegans after 9 different RNAi treatments

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Changes in Caenorhabditis elegans proteome after dnj-21 knockdown

Project description:Dysfunction of the motor subunit of the TIM23 translocase, the PAM complex located on the matrix side of the mitochondrial inner membrane in Saccharomyces cerevisiae, was shown to cause a decrease in mitochondrial protein import and precursor accumulation in the cytosol. We used an analogous model to study the non-mitochondrial response to defective mitochondrial import machinery in Caenorhabditis elegans in which we depleted DNJ-21 as the functional homolog of yeast Pam18. To gain a broader insight in potential changes in Caenorhabditis elegans proteome upon DNJ-21 depletion we performed a quantitative, label-free proteomics analysis. We compared protein levels upon knockdown of dnj-21 (dnj-21 RNAi) with control conditions (Empty vector RNAi). Synchronized N2 wild type worms were grown on NGM plates seeded with E. coli HT115(DE3) transformed with a construct targeting dnj-21 gene or with empty vector L4440 as a control.

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