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Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning

ABSTRACT: Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning

PROVIDER: PRJNA438452 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6841130.fastq.gz	Fastqsanger.gz
	SRR6841140.fastq.gz	Fastqsanger.gz
	SRR6841131.fastq.gz	Fastqsanger.gz
	SRR6841141.fastq.gz	Fastqsanger.gz
	SRR6841132.fastq.gz	Fastqsanger.gz

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Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning

Project description:We sought to determine the impact of chorioamnionitis exposure on the neonatal monocyte H3K4me3 histone modification landscape over the course of fetal and neonatal immune system development using ChIP-seq. H3K4me3 ChIP-seq was performed on umbilical cord blood purified CD14+ monocytes from healthy and chorioamnionitis-exposed extremely preterm neonates (under 30 weeks gestation), late preterm neonates (30-36 weeks gestation), and term neonates (37+ weeks gestation).

2018-08-01 | GSE111873 | GEO

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2018-08-01 | GSE111927 | GEO

Effect of chorioamnionitis exposure on neonatal monocyte transcription

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Project description:Chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq) was then performed to establish the H3K4me3 landscape in neonatal and adult CD14+ monocytes. As development progressed from neonate to adult, monocytes gained the activating mark H3K4me3. The decreased H3K4me3 abundance at immunologically important neonatal monocyte gene promoters correlated with reduced gene expression, providing evidence that neonatal immune cells exist in an epigenetic state that is distinctly different from adults, and that this state contributes to neonatal specific immune responses.

2016-05-27 | GSE81957 | GEO

Exploring specific microRNAs in amniotic fluid for chorioamnionitis

Project description:To identify candidate miRNAs in amniotic fluids as biomarkers for chorioamnionitis, we compared miRNA array data in amniotic fluids between pregnant women with the absence and presence of histological chorioamnionitis.

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Project description:We used single-nuclei sequencign to determine the effect of chorioamnionitis to the developing cerebellum using a rhesus macaque model of chorioamnionitis induced by intra-amniotic LPS.

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Project description:Preterm premature rupture of membranes (PPROM), which precedes approximately 30–40% of preterm births, is the main cause of neonatal morbidity, mortality, and long-term sequelae. In particular, almost half of all PPRPM cases are frequently complicated by subclinical acute inflammation in the placenta and fetal tissue, commonly named as acute histologic chorioamnionitis [HCA]. Increasing evidences suggest that HCA carries additional risks to both the pregnant women and their fetuses, including greater risk of imminent preterm birth, as well as sepsis, neurologic morbidity, and mortality in neonates. More accurate and early prenatal predictive markers (especially noninvasive ones) are urgently needed for identifying subclinical HCA in the context of PPROM.To identify potential biomarkers in the plasma that could predict histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM), using shotgun and targeted proteomic analyses.

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