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Osmostress induced changes of chromatin architecture and transcription in mammalian cells

ABSTRACT: Osmostress induced changes of chromatin architecture and transcription in mammalian cells

PROVIDER: PRJNA438550 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6843220_1.fastq.gz	Fastqsanger.gz
	SRR6843220_2.fastq.gz	Fastqsanger.gz
	SRR6845320.fastq.gz	Fastqsanger.gz
	SRR6845330.fastq.gz	Fastqsanger.gz
	SRR6845340.fastq.gz	Fastqsanger.gz

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Osmostress induced changes of chromatin architecture and transcription in mammalian cells

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Project description:Alternative splicing is a crucial mechanism for gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has a major impact on the regulation of alternative splicing (AS), which is partly mediated through the action of the p38 SAPK. Remarkably, a splicing network analysis revealed a functional connection between p38 and the spliceosome component SKIIP. Depletion of SKIIP abolished a significant part of the p38-mediated alternative splicing.

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The yeast osmostress response is carbon source dependent

Project description:Adaptation to altered osmotic conditions is a fundamental property of living cells and has been studied in particular detail in the yeast Saccharomyces cerevisiae. Yeast cells accumulate glycerol as compatible solute, controlled at different levels by the High Osmolarity Glycerol (HOG) response pathway. Up to now, essentially all osmostress studies in yeast have been performed with glucose as carbon and energy source, which is metabolised by glycolysis with glycerol is as a normal by-product. Here we investigated the response of yeast to osmotic stress when yeast is respiring ethanol as carbon and energy source. Remarkably, yeast cells do not accumulate glycerol under these conditions and it appears that trehalose may partly take over the role as compatible solute. The HOG pathway is activated in very much the same way as in during growth on glucose medium and is also required for osmotic adaptation. Slower volume recovery was observed in ethanol-grown cells as compared to glucose-grown cells. Dependence on key regulators as well as the global gene expression profile were similar in many ways to those previously observed in glucose-grown cells. However, there are indications that cells re-arrange redox-metabolism when respiration is hampered under osmostress, a feature that could not be observed in glucose-grown cells.

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