Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differentially expressed genes in HUVEC following miRNA-146a overexpression

ABSTRACT: Differentially expressed genes in HUVEC following miRNA-146a overexpression

PROVIDER: PRJNA439194 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6868803_1.fastq.gz	Fastqsanger.gz
	SRR6868803_2.fastq.gz	Fastqsanger.gz
	SRR6868804_1.fastq.gz	Fastqsanger.gz
	SRR6868804_2.fastq.gz	Fastqsanger.gz
	SRR6868805_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Differentially expressed genes in HUVEC following miRNA-146a overexpression

Project description:We report that miRNA-146a exerts anti-proliferative effects on endothelial cells in vitro as well as in vivo. In order to obtain insights into potential target genes, we generated samples of HUVEC overexpressing miRNA-146a and RNA sequencing was performed by Novogene (Novogene Bioinformatics Technology, Beijing, China)

2020-03-01 | GSE112059 | GEO

Differentially expressed genes in smooth muscle cells following miRNA-146a overexpression

Project description:Differentially expressed genes in smooth muscle cells following miRNA-146a overexpression

| PRJNA439195 | ENA

Differentially expressed genes in smooth muscle cells following miRNA-146a overexpression

Project description:We report that miRNA-146a exerts anti-proliferative effects on smooth muscle cells in vitro as well as in vivo. In order to obtain insights into potential target genes, we generated samples of SMC overexpressing miRNA-146a and RNA sequencing was performed by Novogene (Novogene Bioinformatics Technology, Beijing, China)

2020-03-01 | GSE112060 | GEO

Differentially expressed genes following ARID1A depletion

Project description:Differentially expressed genes following ARID1A depletion

| PRJNA477786 | ENA

Transcriptomic analysis of targets regulated by miR-146a in primary endothelial cells

Project description:Human vein umbilical endothelial cells (HUVEC) were transfected with pre-miR control and pre-miR 146 (Ambion) in order to identify targets (direct and indirect) downregulated by miR-146a in endothelial cells. 164 transcripts were downregulated with a fold change ≥ 1.2. Total RNA was obtained from cells transfected in HUVEC with pre-miR control and pre-miR 146a. Three independent transfections were performed for each condition. 2 replicates for control re-control and 3 for pre-miR 146a were analyzed.

2013-12-21 | E-GEOD-43016 | biostudies-arrayexpress

Lipopolysaccharide-induced microRNA-146a targets CARD10 and involves in angiogenesis of human umbilical vein endothelial cells

Project description:This study was designed to explore the role of miRNA-146a (miR-146a) and its target genes in the endothelial cells. In this study we have demonstrated that lipopolysaccharide (LPS) induced upregulation of miR-146a in the human umbilical vein endothelial cells (HUVEC) and the induction was blocked by the silencing of the toll-like receptors (TLRs) adaptor molecules MyD88 and nonspecific NF-κB inhibitor BAY 11-7082. In addition, knockdown of miR-146a by transfection of the locked nucleic acid (LNA)-antimiR-146a significantly decreased the increased cell migration and tube formation induced by LPS. A combined analysis of the bioinformatics miRanda algorithms and the whole genome expression microarray of the immunoprecipitated Ago2 ribonucleoprotein complex identified 14 transcripts as the potential target genes. Subsequent transfection with miR-146a precursor pre-miR-146a into the HUVEC validated that the CARD10 was the target gene of the miR-146a both in the transcript and protein level.

2013-09-10 | GSE50619 | GEO

role of miR-146a on Jurkat T cells

Project description:screenning the differentially expressed genes of Jurkat-FF3, Jurkat-miR146a, Jurkat-miR146a-sponge cell lines. To investigate the role of miR-146a on Jurkat T cells, we screened the differentially expressed genes of Jurkat-FF3 (as control), Jurkat-miR146a (as miR-146a overexpression cell line), Jurkat-miR146a-sponge (as miR-146a knock down cell line).

2010-04-03 | E-GEOD-21132 | biostudies-arrayexpress

Data in support of Absence of miRNA-146a differentially alters microglia function and proteome

Project description:MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival. Here, we identified microglia as the main cellular source of miR-146a among mouse CNS resident cells. We further characterized the phenotype of miR-146a KO microglia cells during in vivo demyelination induced by cuprizone (CPZ) and found reduced number of CD11c+ microglia in the KO compared to WT mice. Microglia were also isolated from the brain, and the proteome was analyzed by liquid chromatography mass spectrometry.

2020-06-29 | PXD015939 | Pride

Differentially expressed miRNAs in colorectal cancer

Project description:Differentially expressed miRNAs in colorectal cancer

| PRJNA658901 | ENA

Transcriptomic analysis of targets regulated by miR-146a in primary endothelial cells

2013-12-21 | GSE43016 | GEO