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Comprehensive analysis of H3K9me2 oocytes, together with DNA methylation and expression analysis of G9a conditional KO oocytes and maternal KO preimplantation embryos

ABSTRACT: Comprehensive analysis of H3K9me2 oocytes, together with DNA methylation and expression analysis of G9a conditional KO oocytes and maternal KO preimplantation embryos

PROVIDER: PRJNA445679 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6896870_1.fastq.gz	Fastqsanger.gz
	SRR6896870_2.fastq.gz	Fastqsanger.gz
	SRR6896880_1.fastq.gz	Fastqsanger.gz
	SRR6896880_2.fastq.gz	Fastqsanger.gz
	SRR6896890.fastq.gz	Fastqsanger.gz

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Comprehensive analysis of H3K9me2 oocytes, together with DNA methylation and expression analysis of G9a conditional KO oocytes and maternal KO preimplantation embryos

Project description:We report the first genome-wide landscape of H3K9me2 ChIP-seq profile in mouse oocytes. We also performed whole-genome bisulfite sequencing and RNA-seq analysis of G9a conditional KO oocytes and maternal KO preimplantation embryos. Our findings illuminate the functional importance of G9a in preimplantation development and, in addition, pose a question on the proposed role for H3K9me2 in protection of the maternal genome from active CG demethylation.

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