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MicroRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_1]

ABSTRACT: microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_1]

PROVIDER: PRJNA445920 | ENA |

REPOSITORIES: ENA

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microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_1]

Project description:In the present study, we established organoids using cancer and non-cancer tissues obtained from patients with biliary tract carcinomas and investigated compehensive microRNA expression profiles.

2019-03-15 | GSE112405 | GEO

Gene expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_3]

2019-03-15 | GSE112407 | GEO

microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_2]

2019-03-15 | GSE112406 | GEO

microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_2]

Project description:microRNA expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_2]

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Gene expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_3]

Project description:Gene expression profiles in organoids derived from biliary tract carcinomas [MAA-17164_3]

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microRNA and geneexpression profiles in organoids derived from biliary tract carcinomas

Project description:microRNA and geneexpression profiles in organoids derived from biliary tract carcinomas

| PRJNA445919 | ENA

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Project description:We analyzed sphere cultured biliary tract cancer cell lines and analysed cancer stem cells asociated-differentially expressed genes by microarray analysis. biliary tract cancer stem cells(CSCs) associated DEG

2024-03-27 | GSE233893 | GEO

MicroRNA markers for the diagnosis of pancreatic and biliary tract cancers

Project description:MicroRNAs from serum samples could detect pancreatic and biliary tract cancer patients more accurately than other traditional markers. Prospective miRNA markers for pancreatic/biliary tract cancer were selected in the training cohort. Using these miRNAs, discriminant analysis was performed, and the diagnostic accuracy, sensitivity and specificity were calculated in the test cohort.

2015-03-01 | E-GEOD-59856 | biostudies-arrayexpress

Project description:Tumour and adjacent components from human resected biliary tract cancers were characterised for the expression of immunorelated transcripts

2018-02-14 | GSE90698 | GEO

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.

Project description:Background: RNASeq was performed on organoids derived from livers of normal healthy donors and patients with biliary atresia to characterize transcriptomic signatures. Methods: Organoids generated from livers of normal healthy donors and patients with biliary atresia were cultured either in expansion (undifferentiated: 3 NCOs and 11 BACOs) or differentiation medium (differentiated: 3 BACOs). Liver tissues obtained from deceased-donor subjects served as normal controls (N=3). Total RNA was isolated from organoids and liver biopsy tissue specimens. Results: Organoids from patients with biliary atresia showed abnormal cell polarity, loss of tight junctions, increased permeability and decreased expression of genes related to epidermal growth factor (EGF)- and fibroblast growth factor 2 (FGF2)-signaling. When treated with EGF+FGF2, biliary atresia organoids expressed differentiation and functional markers with restored cell polarity. Conclusion: Organoids from biliary atresia are viable and have evidence of halted epithelial development. The induction of developmental markers, improved cell‐cell junction, and decreased epithelial permeability by EGF and FGF2 identifies potential strategies to promote epithelial maturation and function.

2021-10-25 | GSE186444 | GEO

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