Similar Datasets
Project description:The gut of chicken is mostly colonised with Campylobacter jejuni and with 100 fold less C. coli. The competitive ability of C. coli OR12 over C. jejuni OR1 has been examined in experimental broiler chickens following the observation that C. coli replaced an established C. jejuni intestinal colonisation within commercial chicken flocks reared outdoors (El-Shibiny, A., Connerton, P.L., Connerton, I.F., 2005. Enumeration and diversity of campylobacters and bacteriophages isolated during the rearing cycles of free-range and organic chickens. Applied Environmental Microbiology. 71, 1259-1266).
2015-09-15 | GSE17805 | GEO
Project description:This experiment has been annotated by TAIR (http://arabidopsis.org). We examined transcript profiles triggered by three different arabidopsis R genes that recognize distinct Peronospora parasitica isolates. Experimenter name = Thomas Eulgem Experimenter phone = 43 1 4277 54622 Experimenter fax = 43 1 4277 9546 Experimenter department = Institute of Microbiology and Genetics Experimenter address = Institute of Microbiology and Genetics Experimenter address = Dr. Bohrgasse 9 Experimenter address = Vienna Experimenter zip/postal_code = A-1030 Experimenter country = Austria Keywords: strain_or_line_design
2006-08-15 | GSE5532 | GEO
Project description:Despite Cystic Fibrosis Transmembrane conductance Regulator (CFTR) being identified as the gene responsible for cystic fibrosis (CF), there are multiple CF-causing genetic variants affecting phenotypes in people with CF (pwCF). Animal models generated so far have introduced various mutations in the Cftr gene, but none replicate the genetic diversity found in humans. Yet, CF mice exhibit variable degrees of extra-pulmonary phenotypes, lacking the lung dysfunction and susceptibility to infection that are primary manifestations in humans, thus limiting pathogenic studies. We opted for Collaborative Cross (CC) mice, a genetically diverse animal resource population, to identify a suitable genetic background for CF. Here, we show that ΔF508-Cftr homozygosity in CC037 mice produced a fully penetrant lethal phenotype within two months of age. Early in life, in the absence of mucus production, inflammatory and immune responses arise in the lungs and blood. The CF murine lung exhibits an activated immunoinflammatory and defense response to bacterial pathogens, sharing microbiology with the gut. Intestinal mucosal function shows impaired barrier integrity, provides an environmental niche for bacterial accumulation and triggers inflammation. Treating gut pathology protected CF mice from respiratory and systemic inflammation, establishing the groundwork for inter-organ communication, likely via the gut-lung axis. In sum, we report the first mouse model that reproduces human CF and provides a paradigm for mouse modeling relevant to multiple other genetic disorders. The significance of our findings is fundamental for CF, supporting the role of the gut in lung pathology and suggesting new diagnostic and therapeutic interventions beyond lung-related treatments.
2025-07-30 | GSE273812 | GEO
Project description:Semiconductor sequencing of alkaline degraded total RNA from Pyrococcus furiosus annotated for ”The 23S ribosomal RNA from Pyrococcus furiosus is circularly permuted” published in Frontiers in Microbiology”
2020-11-24 | GSE153501 | GEO
Project description:The gut of chicken is mostly colonised with Campylobacter jejuni and with 100 fold less C. coli. The competitive ability of C. coli OR12 over C. jejuni OR1 has been examined in experimental broiler chickens following the observation that C. coli replaced an established C. jejuni intestinal colonisation within commercial chicken flocks reared outdoors (El-Shibiny, A., Connerton, P.L., Connerton, I.F., 2005. Enumeration and diversity of campylobacters and bacteriophages isolated during the rearing cycles of free-range and organic chickens. Applied Environmental Microbiology. 71, 1259-1266). Five independent DNA preps of C. jejuni RM1221 were labelled with Cy 5 independently and they were mixed well which was used as the control. OR1 and OR12 were labelled with Cy 3 independently and equal concentration of the control and sample DNA were used for hybridisation. Three biological replicates were done for each slide. The supplementary file (linked at the foot of this record) represents the averaged normalised values for each experimental condition (3replicates/experimental condition).
2015-09-15 | E-GEOD-17805 | biostudies-arrayexpress