Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic analysis of microglia 4 month old ML4 Fabry and control mice

ABSTRACT: Transcriptomic analysis of microglia 4 month old ML4 Fabry and control mice

PROVIDER: PRJNA449393 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6973870.fastq.gz	Fastqsanger.gz
	SRR6973870_1.fastq.gz	Fastqsanger.gz
	SRR6973870_2.fastq.gz	Fastqsanger.gz
	SRR6973871.fastq.gz	Fastqsanger.gz
	SRR6973871_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 27

Similar Datasets

Transcriptomic analysis of microglia 4 month old ML4 Fabry and control mice

Project description:the study aims to describe the modifications occurring the microglia isolated from mouse models of 2 lysosomal storage diseases: Mucolipidosis type 4 and fabry disease.

2019-01-01 | GSE112895 | GEO

Transcription profiling of mouse kidney from control-fed 5-month-old, control-fed 30-month-old and calorie restricted 30 month-old C57BL/6 mice

Project description:Gene expression profiles of kidney tissue from control-fed 5-month-old, control-fed 30-month-old and calorie restricted 30 month-old C57BL/6 mice.

2007-12-13 | E-GEOD-459 | biostudies-arrayexpress

Gene expression profile at single-cell level of microglia from 3-, 14- and 24-month-old female mouse brains

Project description:Microglia are important immune cells in the brain. Microglia undergo a series of alterations during aging and increase the susceptibility to brain dysfunctions. However, the characteristics of microglia during the aging process are not fully understood. In this study, we mapped transcriptional and epigenetic profiles of microglia from 3- to 24-month-old mice. We observed unexpected gender divergences and identified age-dependent microglia (ADEM) genes in the aging process. We then compared characteristics between microglial aging and activation. To dissect the function of aged microglia excluding the influence from other aged brain cells, we established an accelerated microglial turnover model without directly affecting other brain cells. By this model, we achieved aged microglia in non-aged brains and confirmed that aged microglia per se contribute to cognitive decline. Collectively, we provide a comprehensive resource to decode the aging process of microglia, shedding light on how microglia maintain brain functions.

2023-07-25 | GSE207932 | GEO

ATAC-seq of microglia from 3-, 14- and 24-month-old female mouse brains treated by LPS or PBS

2023-07-25 | GSE208346 | GEO

Comparison of microglia of old vs. young ischemic male mice

Project description:We subjected old (21-22 month) and young (3-4 month) male C57BL/6 mice to 45 min transient oclusion of the middle cerebral artery and obtained the brain four days later. We obtained bodipy+ microglia from the ischemic brain tissue by FACS.

2022-11-29 | GSE209732 | GEO

Comparison of gene expression in seminiferous tubules of 3 month old calf versus 9 month old calf using RNA-Seq

Project description:We sequenced RNA from seminiferous tubules of 3 month old calf versus 9 month old calf

2019-02-18 | GSE78526 | GEO

Expression data from 18-month old rats

Project description:Expression data from 18-month old rats

| PRJNA592911 | ENA

Comparing expression in livers of 1-month vs 6-month old mice

Project description:To look for age-related changes in the liver, we used RNAseq gene expression analysis to characterize mRNA expression profile in livers from 1-month vs. 6-month-old mice

2019-08-01 | GSE103069 | GEO

scRNA-seq of brain cells from 3- and 24-month-old mouse brains

2023-07-25 | GSE208292 | GEO

Fabry nephropathy transcriptome

Project description:Fabry nephropathy (FN) is a rare disorder caused by mutations in the alpha-galactosidase A gene. In this study we aim at providing a framework allowing selection of biomarkers and drug-targets. Two independent Fabry Nephropathy cohorts (FA.NO and CH.RO) were subjected to RNAseq from archival kidney biopsies taken prior and up to 10 years of Enzyme Replacement Therapy. Four compartments were laser capture microdissected (glomeruli, proximal tubuli, distal tubuli and arteries). We found several pathways that were consistently altered and that these kidney compartments’ transcriptional landscapes can be leveraged in the search for drug-targets and biomarkers.

2023-07-17 | GSE178947 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data