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Conditional DICER1 knockout hESCs

ABSTRACT: Conditional DICER1 knockout hESCs

PROVIDER: PRJNA450977 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7039831_1.fastq.gz	Fastqsanger.gz
	SRR7039831_2.fastq.gz	Fastqsanger.gz
	SRR7039832_1.fastq.gz	Fastqsanger.gz
	SRR7039832_2.fastq.gz	Fastqsanger.gz
	SRR7039833_1.fastq.gz	Fastqsanger.gz

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Conditional DICER1 knockout hESCs

Project description:We report the generation and characterization of DICER1-deficient hESCs. We uncover an unexpected requirement for DICER1 as well as essential pro-survival roles of members of the mir-302- 367 and mir-371- 373 clusters in hESCs. Our work provides a robust platform for interrogating microRNA function in hESC and differentiation.

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Expression data from postnatal mouse apical and basal organ of Corti from Dicer1 conditional knockout and littermate control cochleae.

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