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Gene expression profile of 4/7 ICR modified T cells compared to control ΔIL4R T cells

ABSTRACT: Gene expression profile of 4/7 ICR modified T cells compared to control ΔIL4R T cells

PROVIDER: PRJNA451001 | ENA |

REPOSITORIES: ENA

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Gene expression profile of 4/7 ICR modified T cells compared to control ΔIL4R T cells

Project description:The objective of this experiment was to compare the transcriptional profile of 4/7 ICR (IL4R ectodomain fused to IL7R endodomain) vs control ΔIL4R (truncated version that lacks an endodomain) modified T cells. RNA samples were isolated from trangenic T cells generated from three independent donors.

2018-04-20 | GSE113389 | GEO

Gene expression profile of SmarT-cells compared to control T cells modified to express ΔCAR, ΔTGFbRII and ΔIL4R

Project description:The objective of this experiment was to compare the transcriptional profile of T cells modified to express CAR, TBBR and 4/7 ICR (i.e. SmarT-cells) against control T cells expressing the delta constructs (i.e. ΔCAR, ΔTGFbRII and ΔIL4R). RNA samples were isolated from trangenic T cells generated from three independent donors.

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Gene expression profile of TBBR modified T cells compared to control ΔTGFbRII T cells

Project description:Gene expression profile of TBBR modified T cells compared to control ΔTGFbRII T cells

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Gene expression profile of SmarT-cells compared to control 1G CAR T cells

Project description:The objective of this experiment was to compare the transcriptional profile of T cells modified to express CAR, TBBR and 4/7 ICR (i.e. SmarT-cells) against control 1G CAR T cells expressing CD3z endodomain. RNA samples were isolated from trangenic T cells generated from three independent donors.

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Gene expression profile of SmarT-cells compared to control T cells modified to express ΔCAR, ΔTGFbRII and ΔIL4R

Project description:Gene expression profile of SmarT-cells compared to control T cells modified to express ΔCAR, ΔTGFbRII and ΔIL4R

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Gene expression profile of TBBR modified T cells compared to control ΔTGFbRII T cells

Project description:The objective of this experiment was to compare the transcriptional profile of TBBR (TGFbRII ectodomain fused to 41BB endodomain) vs control ΔTGFbRII (truncated version that lacks an endodomain) modified T cells. RNA samples were isolated from trangenic T cells generated from three independent donors.

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Transcriptome profile of HeLa COL1G610C transfected cells compared to control cells

Project description:Transcriptome profile of HeLa COL1G610C transfected cells compared to control cells

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Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice

Project description:ICR-derived glomerulonephritis (ICGN) mice is a novel inbred strain of mice with a hereditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been suggested. To identify additional associative factors and to better understand onset mechanism of nephrotic syndrome in ICGN mice, comprehensive gene expression analysis using DNA microarray was conducted. Immune-related pathways were markedly altered in ICGN mice kidney as compared with ICR mice. Furthermore, gene expression level of complement component 1, s subcomponent (C1s), whose human homologue has been reported to associate with lupus nephritis, was markedly low in ICGN mice kidney. RNA from renal cortex of 4- and 8-week-old ICGN and ICR mice was extracted and processed for hybridization on Affymetrix microarrays (N=3).

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Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice

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ICR mice

Project description:ICR mice Targeted loci

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