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Expressioin data from mouse colorectal cancer grown in healthy liver or fatty liver with or without antiangiogenic treatment

ABSTRACT: Expressioin data from mouse colorectal cancer grown in healthy liver or fatty liver with or without antiangiogenic treatment

PROVIDER: PRJNA451408 | ENA |

REPOSITORIES: ENA

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Expressioin data from mouse colorectal cancer grown in healthy liver or fatty liver with or without antiangiogenic treatment

Project description:Cancers located adjacent to adipose tissues often show intrinsic and acquired resistance to antiangiogenic therapy. The resistance is developed potentially via tumor cell metabolic paradigm shift. We use microarrays to detail the gene expression upon tumor grown in the healthy or fatty liver with or without antiangiogenic treatment. Inflammatory profile, fatty acid oxidation-related genes, FFA transporter-related genes, and energy metabolism-related genes have been examined.

2018-04-24 | GSE113508 | GEO

fatty liver

Project description:fatty liver tissue sequencing

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Proteomic analysis of fatty liver induced by starvation of medaka fish larvae

Project description:When medaka fish larvae are grown in the absence of exogenous nutrition, the liver becomes dark and positive to Oil Red O staining. We examined the the mechanism of this starvation-induced development of fatty liver by proteomic analysis using livers obtained from larvae grown in the presence or absence of 2% glucose at 5 days-post-hatch.

2024-04-08 | PXD041411 | JPOST Repository

Acquired paternal inheritance fatty liver transcriptomes induced by high-fat diet

Project description:Many acquired traits related to fat metabolism are inherited, and nutritional factors can induce fatty liver in chickens. We found that the paternal fatty livers induced by high-fat diet in Jingxing-Huang chickens were inherited, but the molecular mechanisms of inherited fatty liver in chickens are far from clear. The goals of this study are to compare liver transcriptome profiling (RNA-seq) in F1 generation to screen candidate genes for acquired fatty liver. Compared to birds without fatty liver in the control group, the paternal group exhibited altered hepatic gene expression profiles, including up-regulation of several key genes involved in fatty acid metabolism, lipid metabolism and glucose metabolism (ACACA, FASN, SCD, ACSL5, FADS2, FABP1, APOA4 and ME1). This study uniquely revealed that acquired fatty liver in cocks can be inherited. The hepatic gene expression profiles were altered in chickens with the inherited phenotype of acquired paternal fatty liver and several genes could be candidate biomarkers.

2018-04-09 | GSE111909 | GEO

Hepatocyte mARC1 Promotes Fatty Liver Disease

Project description:Hepatocyte mARC1 Promotes Fatty Liver Disease

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Hepatocyte mARC1 Promotes Fatty Liver Disease

Project description:Hepatocyte mARC1 Promotes Fatty Liver Disease

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Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver

2012-10-01 | GSE40334 | GEO

Industrial trans fatty acids stimulate SREBP2-mediated cholesterogenesis and promote non-alcoholic fatty liver disease [liver]

Project description:Industrial trans fatty acids stimulate SREBP2-mediated cholesterogenesis and promote non-alcoholic fatty liver disease [liver]

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Expression data from miRNAs in colorectal cancer tissues with and without liver metastasis

Project description:The purpose of this study is to identify miRNAs involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms. A total of 39 miRNAs were identified to be differentially expressed between 16 primary CRC tissues with liver metastases and 16 CRC tissues without liver metastases from 32 patients by Affymetric miRNA microarrays. 16 coloretcal cancer tissues with liver metastasis and 16 colorectal cancer tissues without liver metastasis were included in this study for RNA extraction and hybridization on Affymetrix microarrays. We sought to identify the differentially expressed miRNAs between colorectal cancer tissues with and without liver metastasis.

2013-12-10 | E-GEOD-53159 | biostudies-arrayexpress

Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver

Project description:Alcohol induced fatty liver cause a dangerous health problem and is the major cause of morbidity and mortality worldwide. Garlic (Allium sativum) is documented to possess anti-fatty liver properties. However the exact molecular mechanisms are unknown. The main aim of this experiment is to elucidate the underlying pathways through which garlic ameliorates alcohol induced fatty liver. Dially disulfide and garlic oil were the garlic compounds used in this study. Leiber DeCarli ethanol liquid diet was to induce fatty liver in C57BL/6 mice model. Also the expression impaired by alcohol induced fatty liver is another aim of this study. Leiber-Decarli ethanol diet was used to induce fatty liver in male C57BL/6 mice (n=12). For control, Lieber-DeCarli liquid control diet was fed to mice (n=4). The control mice were pair-fed to the ethanol mice. After adaptation, the ethanol fed mice were divided into three groups viz. alcohol (n=4), dially disulfide [DADS] (n=4) and garlic oil [GO] (n=4). The study started with the administration of DADS (15 mg/kg bw) or GO (50 mg/kg bw) mixed in 0.1 ml olive oil through gavage. For the control and alcohol groups, same amount of olive oil (0.1 ml) was gavaged. The mice were gavaged daily for 4 weeks. The mice were euthanized by CO2 and blood was collected by cardiac puncture. Liver, kidney, spleen, lungs and hearts were collected and their weights recorded. A portion of liver was snap frozen in liquid nitrogen (200 mg) for RNA extraction.

2012-10-01 | E-GEOD-40334 | biostudies-arrayexpress

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