Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:Pseudogastromyzon fasciatus belonging to the family Gastromyzontidae is a good model for phylogeny and zoogeography research. The complete mitochondrial genome of P. fasciatus was sequenced in this study. The genome sequence is 16,563 bp in length, comprising 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and one control region. Overall base composition is 29.70% A, 25.16% T, 16.53% G, and 28.60% C. The result of phylogenetic analysis indicates that P. fasciatus mitogenome is close to that of P. myersi.
Project description:Pseudogastromyzon changtingensis belonging to the family Gastromyzontidae is a good model for phylogeny and zoogeography research. In the present paper, the sequenced mitochondrial genome of P. changtingensis is of 16573?bp in length, and encodes 13 typical protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one control region. The result of phylogenetic analysis demonstrates that P. changtingensis is close to that of P. fasciatus.
