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Gene expression profiles of wild-type and PERK-deficient cells during activation of OXPHOS

ABSTRACT: Gene expression profiles of wild-type and PERK-deficient cells during activation of OXPHOS

PROVIDER: PRJNA453130 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7058961.fastq.gz	Fastqsanger.gz
	SRR7058962.fastq.gz	Fastqsanger.gz

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Gene expression profiles of wild-type and PERK-deficient cells during activation of OXPHOS

Project description:Intracellular ATP is mainly produced by the glycolysis pathway in culture cells incubated with high-glucose medium, whereas ATP production is switched to the OXPHOS pathway by culturing with the no-glucose medium. To elucidate the potential function of PERK during activation of OXPHOS pathway, we perfomed RNA-sequencing analayais using wild-type and PERK-deficient HEK293 cells.

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The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

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