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Homo sapiens

ABSTRACT: Role of JMJD1A/KDM3A in HCT116 colorectal cancer cells

PROVIDER: PRJNA453378 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7061540_1.fastq.gz	Fastqsanger.gz
	SRR7061540_2.fastq.gz	Fastqsanger.gz
	SRR7061581_1.fastq.gz	Fastqsanger.gz
	SRR7061581_2.fastq.gz	Fastqsanger.gz
	SRR7061582_1.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:Expression data from HCT116 colorectal cancer cells.

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The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells

Project description:The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity and tumor progression. We matched transcriptomic and ChIP-Seq profiles to decipher a genome-wide regulatory network of epigenetic control by KDM3A in prostate cancer cells. ChIP-Seq experiments monitoring histone 3 lysine 9 (H3K9) methylation marks show global histone demethylation effects of KDM3A. Combined assessment of histone demethylation events and gene expression changes presented major transcriptional activation suggesting that distinct oncogenic regulators may synergize with the epigenetic patterns by KDM3A. Pathway enrichment analysis of cells with KDM3A knockdown prioritized androgen signaling indicating that KDM3A plays a key role in regulating androgen receptor activity. Matched ChIP-Seq and knockdown experiments of KDM3A in combination with ChIP-Seq of the androgen receptor resulted in a gain of H3K9 methylation marks around androgen receptor binding sites of selected transcriptional targets in androgen signaling including positive regulation of KRT19, NKX3-1, KLK3, NDRG1, MAF, CREB3L4, MYC, INPP4B, PTK2B, MAPK1, MAP2K1, IGF1, E2F1, HSP90AA1, HIF1A, and ACSL3. The cancer systems biology analysis of KDM3A-dependent genes identifies an epigenetic and transcriptional network in androgen response, hypoxia, glycolysis, and lipid metabolism. Genome-wide ChIP-Seq data highlights specific gene targets and the ability of KDM3A to control oncogenic pathways in prostate cancer cells.

2019-05-15 | GSE109748 | GEO

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Project description:Gene expression in HCT116 cells after JMJD1A/1B depletion

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Project description:Comparison of transcriptome between HCT116 and NCLX knockout HCT116 colorectal cancer cells

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Project description:colorectal cancer cell line HCT116 and oxaliplatin-resistant colorectal cancer cell line HCT116/L Transcriptome

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Identification of JMJD1A and JMJD2B Target Genes in Hypoxic Ovarian Cancer Cells

Project description:The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. Using transcript profiling, we have identified genes that are regulated by JMJD1A and JMJD2B in both normoxic and hypoxic conditions in SKOV3ip.1 ovarian cancer cells. This dataset includes expression data obtained from exposing ovarian cancer cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B. These data were used to both identify functional overlap between each histone demethylase, as well as identify effectors of tumor growth mediated by JMJD2B (KDM4B) in normoxia and hypoxia.

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Project description:BORIS knockdown in colorectal cancer cells HCT116 and Caco-2

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Project description:HCT116 colorectal cancer cell Raw sequence reads

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Project description:HCT116 colorectal cancer cell Raw sequence reads

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Identification of JMJD1A and JMJD2B target genes in hypoxic colon carcinoma cells

Project description:The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. This dataset includes expression data obtained from exposing colon carcinoma cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B.

2021-11-03 | GSE166991 | GEO

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