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Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor [ChIP-Seq]

ABSTRACT: Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor [ChIP-Seq]

PROVIDER: PRJNA464296 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7126180.fastq.gz	Fastqsanger.gz
	SRR7126181.fastq.gz	Fastqsanger.gz
	SRR7126182.fastq.gz	Fastqsanger.gz
	SRR7126179.fastq.gz	Fastqsanger.gz

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Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor [Agilent]

Project description:Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. In this paper we report an AP2 family transcription factor AP2-FG is responsible for female-specific gene expression.

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Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor [ChIP-Seq]

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Project description:Sex-specific gene regulation in malaria parasites by an AP2 Family Transcription Factor

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Comparison of gene expression between wild type and AP2-L KO parasites

Project description:In the rodent malaria parasite Plasmodium berghei, we found that an AP2 family transcription factor designated AP2-L plays a critical role in the development of the liver stage. Using DNA microarray analysis we showed that the expression of several genes, including those of parasitophorous vacuole membrane proteins, was significantly decreased in the early liver stage of AP2-L-depleted parasites. Gene expression of P. berghei liver stages was compared between wild type and AP2-L KO parasites. Liver stage parasites were cultured for 24h using HepG2 cells. Ten and seven biologically independent experiments were performed for wild type and AP2-L KO parasites, respectively.

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Comparison of gene expression between wild type and AP2-G KO parasites.

Project description:In the rodent malaria parasite Plasmodium berghei, we found that an AP2 family transcription factor designated AP2-L plays a critical role in the development of the liver stage. Using DNA microarray analysis we showed that the expression of several genes, including those of parasitophorous vacuole membrane proteins, was significantly decreased in the early liver stage of AP2-L-depleted parasites. Gene expression of P. berghei sporozoites was compared between wild type and AP2-G KO parasites. Five biologically independent experiments were performed for each genotype.

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Project description:Sporozoite-specific genes were induced in parasites that express AP2-O whose AP2 domain was swapped with that of AP2-Sp. DNA construct encoding AP2 domain of AP2-Sp was introduced into P. bergei schizonts. It was integrated into the locus of the endogenious AP2-O gene, resulting in swap of the AP2-domain (AP2-O::Sp parasites). Gene expression was analyzed in ookinetes cultured for 20h.

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