Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Salmonella enterica subsp. enterica serovar Derby

ABSTRACT: Salmonella derby St71 isolated in human in france 2014-2015

PROVIDER: PRJNA464303 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Salmonella enterica subsp. enterica serovar Derby

Project description:Salmonella enterica subsp. enterica serovar Derby Genome sequencing

| PRJNA954139 | ENA

A single missense mutation in hilD is responsible for further adaptation of a Salmonella Derby lineage to swine and reduced risk to human health

Project description:Salmonella enterica variants exhibit diverse host adaptation, outcome of infection, and associated risk to humans. Analysis of 6,335 Salmonella isolates recovered from integrated human-animal surveillance in Emilia Romagna region, Northern Italy, (human population ca 4,500,000), from 2012 to 2017 showed that Salmonella enterica serovar Derby constitutes a swine associated serovar in this epidemiological context while representing also a significant causative agent of human infections. Comparison of the distribution of subtypes of Salmonella Derby from human and swine identified isolates with a distinct PFGE profile that were significantly less isolated in human infections than in swine infections compared to all other subtypes. Here we show that isolates with this PFGE profile form a distinct phylogenetic sub-clade within Salmonella Derby and exhibit a marked reduction in invasion and replication in human epithelial cells but a relatively small reduction in swine epithelial cells, in line with the epidemiological evidence. A single missense mutation in hilD, that encodes the master-regulator of the Salmonella Pathogenicity Island 1 (SPI-1), was identified in this lineage of Salmonella Derby. Since SPI-1 encodes for a primary system of Salmonella invasion into epithelial cells, we investigated the role of the observed mutation in detail. We demonstrated that the missense mutation results in a loss of function of HilD that accounts for the reduced invasion and replication in human epithelial cells while showing a relatively small impact on the interaction with swine cells. This finding is suggestive of a mechanism of invasion alternative to SPI-1 in the Salmonella-swine combination

2020-12-16 | GSE142220 | GEO

Salmonella enterica subsp. enterica serovar Derby

Project description:Salmonella Derby: genetic and antimicrobial diversity in Germany between 2000 and 2018

| PRJNA646595 | ENA

Salmonella enterica subsp. enterica serovar Derby strain:Sa64

Project description:Salmonella enterica subsp. enterica serovar Derby strain:Sa64 Genome sequencing

| PRJNA507313 | ENA

Salmonella enterica subsp. enterica serovar Derby str. 626

Project description:Salmonella enterica subsp. enterica serovar Derby str. 626 Genome sequencing and assembly

| PRJNA78403 | ENA

Salmonella enterica subsp. enterica serovar Derby strain:07CR553

Project description:Salmonella enterica subsp. enterica serovar Derby strain:07CR553 Genome sequencing and assembly

| PRJNA270707 | ENA

Salmonella enterica subsp. enterica serovar Derby strain:SC968

Project description:Salmonella enterica subsp. enterica serovar Derby strain:SC968 Genome sequencing and assembly

| PRJNA506323 | ENA

Salmonella enterica subsp. enterica serovar Derby strain:Sa79

Project description:Salmonella enterica subsp. enterica serovar Derby strain:Sa79 Genome sequencing and assembly

| PRJNA522330 | ENA

Salmonella Derby

Project description:Salmonella enterica subspecies enterica serovar Derby from Portugal

| PRJEB56929 | ENA

Salmonella enterica subsp. enterica strain:derby

Project description:Salmonella enterica subsp. enterica strain:derby Genome sequencing and assembly

| PRJNA391404 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data