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Transcriptomes and methylomes from naïve CD4+ T-cells from infants and children with and without food allergy

ABSTRACT: Transcriptomes and methylomes from naïve CD4+ T-cells from infants and children with and without food allergy

PROVIDER: PRJNA464396 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7123400_1.fastq.gz	Fastqsanger.gz
	SRR7123400_2.fastq.gz	Fastqsanger.gz
	SRR7123410_1.fastq.gz	Fastqsanger.gz
	SRR7123410_2.fastq.gz	Fastqsanger.gz
	SRR7123420_1.fastq.gz	Fastqsanger.gz

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Methylomes from naïve CD4+ T-cells from infants and children with and without food allergy [methylation]

Project description:Here we studied the epigenetic regulation of the naïve CD4+ T-cell activation response among children with IgE-mediated food allergy. Using integrated DNA methylation and transcriptomic profiling, we found that food allergy in infancy is associated with dysregulation of T-cell activation genes. Reduced expression of cell cycle related targets of the E2F and MYC transcription factor networks, and remodeling of DNA methylation at metabolic (RPTOR, PIK3D, MAPK1, FOXO1) and inflammatory genes (IL1R, IL18RAP, CD82) were associated with poorer T-lymphoproliferative responses in infancy after polyclonal activation of the T-cell receptor.

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Project description:Methylomes from naïve CD4+ T-cells from infants and children with and without food allergy [methylation]

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Transcriptomes from naïve CD4+ T-cells from infants and children with and without food allergy [RNA-seq]

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Transcriptomes and methylomes from naïve CD4+ T-cells from infants and children with and without food allergy

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