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SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

ABSTRACT: SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

PROVIDER: PRJNA470678 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7140340_1.fastq.gz	Fastqsanger.gz
	SRR7140340_2.fastq.gz	Fastqsanger.gz
	SRR7140341_1.fastq.gz	Fastqsanger.gz
	SRR7140341_2.fastq.gz	Fastqsanger.gz
	SRR7140342_1.fastq.gz	Fastqsanger.gz

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SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds

| PRJNA470673 | ENA

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

| PRJNA470681 | ENA

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

| PRJNA470680 | ENA

Transcriptome of wild type and Shh limb buds at E10.5

Project description:The transcriptome of mouse limb buds of Shh mutant embryos was compared to the transcriptome of limb buds of wild type embryos at embryonic day E10.5

2011-05-01 | E-MEXP-3142 | biostudies-arrayexpress

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114255 | GEO

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114253 | GEO

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114252 | GEO

H3K27ac in WT and Shh-/-, and Shh-/-;Gli3-/- E10.5 limb buds

Project description:Purpose: The response to Hedgehog signaling in the limb is driven by GLI bound enhancers. While most Hh targets in the developing limb bud appear to be regulated by the activity of GLI-repressor, the role of GLI activator in this regulation is unclear. Here we assess the roles of GLI activator and repressor in regulating H3K27ac to activate their enhancers. Methods: ChIP-seq was performed in Embryonic day 10.5 mouse limb buds from WT, Shh-/- and Shh-/-Gli3-/- embryos Results: We found that most GLI binding regions can be activated in the absence of both GLI activator and repressor, while a small subset require GLI activator for activity. These indicate that most GLI enhancers in the limb are regulated by GLI repression.

2020-01-21 | GSE133712 | GEO

H3K27ac in WT and Shh-/-, and Shh-/- Gli3-/- E10.5 limb buds

Project description:H3K27ac in WT and Shh-/-, and Shh-/- Gli3-/- E10.5 limb buds

| PRJNA552304 | ENA

Gene expression changes in limb buds of Nipbl-haploinsufficient mice

Project description:Multiple genes are dysregulated in hindlimb buds of Nipbl-deficient embryos. In all, more than 1000 limb bud genes were found to be significantly altered in expression by microarray analysis of E10.5 mouse hindlimb buds. Small changes in expression (mostly decreases) were observed for genes involved in FGF, BMP, and SHH pathways, as well as numerous genes involved in the Wnt/planar cell polarity signaling pathway. Genes involved in the Mediator complex, Cohesin function, and Hox gene expression and functions were also dysregulated in Nipbl deficient limb buds. Microarray analysis using RNA extracted from E10.5 hindlimb limb buds harvested from stage-matched Nipbl+/- (n=12) and wildtype (n=12)

2014-08-30 | E-GEOD-60932 | biostudies-arrayexpress

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