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Temporal profile of germ-free and conventionally raised male mice (epididymal white adipose tissue (WAT))

ABSTRACT: Temporal profile of germ-free and conventionally raised male mice (epididymal white adipose tissue (WAT))

PROVIDER: PRJNA471296 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7162040_1.fastq.gz	Fastqsanger.gz
	SRR7162040_2.fastq.gz	Fastqsanger.gz
	SRR7162050_1.fastq.gz	Fastqsanger.gz
	SRR7162050_2.fastq.gz	Fastqsanger.gz
	SRR7162060_1.fastq.gz	Fastqsanger.gz

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Temporal profile of germ-free and conventionally raised male mice (epididymal white adipose tissue (WAT))

Project description:Gut microbiota and the circadian clock both regulate metabolism. The circadian clock and associated feeding rhythms were shown to impact on the microbial community. However, to what extent gut microbiota reciprocally affect daily rhythms of gene expression and physiology in the host remains elusive. Here, we analyzed the transcriptomes of male and female germ-free mice. While this revealed subtle changes in circadian clock gene expression in liver, intestine, and white adipose tissue, germ-free mice showed considerably altered expression of genes associated to rhythmic physiology. Strikingly, absence of microbiome severely compromised liver sex-dimorphism at the transcriptome and metabolome level. Their sex-specific rhythmicity was strongly attenuated. The resulting feminization of male and masculinization of female hepatic gene expression in germ-free animals is likely caused by altered sex-dimorphism in sex and growth hormone secretion, linked to differential activation of xenobiotic receptors. This defines a novel mechanism by which the gut microbiome regulates host metabolism.

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Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

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Project description:Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Three different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CONV-R, 4 WT GF, 6 Myd88 -/- GF) and expression profiles were determines using the Affymetrix Mouse Gene 1.0ST platform.

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Temporal profiles of germ-free and conventionally raised female and male mice (LIVER)

Project description:Temporal profiles of germ-free and conventionally raised female and male mice (LIVER)

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Temporal profile of germ-free and conventionally raised male mice (DUODENUM and ILEUM)

Project description:Temporal profile of germ-free and conventionally raised male mice (DUODENUM and ILEUM)

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Transcriptional profiling of intestinal tissue samples from germ-free and conventionally raised mice which are either wild-type or Myd88-/-

Project description:Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Four different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CONV-R, 4 WT GF, 6 Myd88 -/- GF) and expression profiles were determines using the Affymetrix Mouse Gene 1.0ST platform. 77 samples remained after quality control.

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2022-01-01 | GSE182725 | GEO

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