Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Splicing and epigenetic factors jointly regulate epidermal differentiation

ABSTRACT: Splicing and epigenetic factors jointly regulate epidermal differentiation

PROVIDER: PRJNA471690 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7171540_1.fastq.gz	Fastqsanger.gz
	SRR7171540_2.fastq.gz	Fastqsanger.gz
	SRR7171532_1.fastq.gz	Fastqsanger.gz
	SRR7171532_2.fastq.gz	Fastqsanger.gz
	SRR7171533_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Splicing and epigenetic factors jointly regulate epidermal differentiation

Project description:We report the effects of silencing SRSF1 or ZMAT2 in human epidermal stem cells on the transcriptome of epidermal stem cells. We found that silencing ZMAT2 or SRSF1 affects global splicing, however, ZMAT2 seems to regulate splicing of a smaller more specific subset of genes.

2018-10-18 | GSE114529 | GEO

Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation

Project description:We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for epidermal differentiation while with normal glucose condition, DDX21 was re-localized from nucleolus to nucleoplasm, bind to splicing factors and mRNA introns more to regulate splicing of key differentiation factors and promote epidermal differentiation.

2023-01-05 | PXD028561 | Pride

MBNL splicing factors regulate the microtranscriptome of skeletal muscles

Project description:MBNL splicing factors regulate the microtranscriptome of skeletal muscles

| PRJNA1030014 | ENA

MBNL splicing factors regulate the microtranscriptome of skeletal muscles [RNA-Seq]

Project description:MBNL splicing factors regulate the microtranscriptome of skeletal muscles [RNA-Seq]

| PRJNA1119486 | ENA

MBNL splicing factors regulate the microtranscriptome of skeletal muscles [smallRNA-Seq]

Project description:MBNL splicing factors regulate the microtranscriptome of skeletal muscles [smallRNA-Seq]

| PRJNA1119478 | ENA

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (CLIP-Seq)

Project description:Glucose is an important cellular energy source, however, glucose’s function as a second messenger remains relatively unexplored. Here, we find that glucose binds directly to DDX21 to regulate its function during epidermal differentiation. Specifically, glucose binds to the ATP-binding domain of DDX21 to induce a conformational change and inhibit helicase activity. Glucose binding inhibits the dimerization of DDX21 leading to re-localization from the nucleolus to the nucleoplasm and reassembly of DDX21 into larger protein complexes, increasing its association with splicing factors. This occurs during keratinocyte differentiation, where glucose accumulation is necessary, and results in DDX21 binding to RNA processing proteins and mRNA introns. Consequently, DDX21 regulates the splicing of key differentiation factors and promotes epidermal differentiation in a glucose-dependent manner. These findings reveal a novel mechanism of glucose regulation of cell signaling.

2023-01-02 | GSE189911 | GEO

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (ChIP-Seq)

2023-01-02 | GSE189910 | GEO

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (CUT&RUN)

2023-01-02 | GSE215313 | GEO

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq II)

2023-01-02 | GSE189912 | GEO

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq I)

2023-01-02 | GSE189414 | GEO