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Endovascular progenitors invade melanoma tumors and differentiate towards a variety of vascular beds to promote tumor metastasis

ABSTRACT: Endovascular progenitors invade melanoma tumors and differentiate towards a variety of vascular beds to promote tumor metastasis

PROVIDER: PRJNA471691 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7171520_1.fastq.gz	Fastqsanger.gz
	SRR7171520_2.fastq.gz	Fastqsanger.gz
	SRR7171530_1.fastq.gz	Fastqsanger.gz
	SRR7171530_2.fastq.gz	Fastqsanger.gz
	SRR7171521_1.fastq.gz	Fastqsanger.gz

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Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis.

Project description:Tumor vascularization is a hallmark of cancer central to disease progression and metastasis. Current anti-angiogenic therapies have limited success prompting the need to better understand the cellular origin of tumor vessels. Using fate-mapping analysis of endothelial cell populations in melanoma, we report the very early infiltration of endovascular progenitors (EVP) in growing tumors. These cells harbored self-renewal and reactivated the expression of SOX18 transcription factor, initiating a vasculogenic process as single cells, progressing towards a transit amplifying stage and ultimately differentiating into more mature endothelial phenotypes that comprised arterial, venous and lymphatic subtypes within the core of the tumor. Molecular profiling by RNA sequencing of purified endothelial fractions characterized EVPs as quiescent progenitors remodeling the extracellular matrix with significant paracrine activity promoting growth. Functionally, EVPs did not rely on VEGF-A signaling whereas endothelial-specific loss of Rbpj depleted the population and strongly inhibited metastasis. The understanding of endothelial heterogeneity opens new avenues for more effective anti-vascular therapies in cancer.

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Endovascular progenitors invade melanoma tumors and differentiate towards a variety of vascular beds to promote tumor metastasis

Project description:Tumors have the capacity to trigger the formation of blood vessels allowing them to spread to other body parts. We examined here the stem cells that form arteries and veins within tumors and propose that their inhibition reduces metastatic spread.

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Endovascular Device for Endothelial Cell Sampling

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Project description:We developed a new technique named as Differential Systemic Decellularization in vivo (DISDIVO) for the molecular profiling of vascular beds throughout the body. This method can by applied to murine models. Thus, the data provided here correspond to mice vascular beds obtained in vivo by DISDIVO.

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Implication of VSMC heterogeneity among arterial beds in vascular calcification

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Meiofauna communities from seagrass beds

Project description:Meiofauna communities from seagrass beds Raw sequence reads

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Gene expression profiling of myofibroblasts in young and aged day 5 wound beds

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